Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.73 |
| ▸ | DHODH | Q02127 | 2/20 | 0.73 |
| ▸ | ACHE | P22303 | 6/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.58 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.48 |
| ▸ | MARK3 | P27448 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6581381 | 0.88 | PARP1 (0.64) | PARP1DHODHCHEK2CHEK1MAP4K4 | |
| SCHEMBL3578485 | 0.86 | PARP1 (0.96) | PARP1DHODHACHECHEK2CHEK1 | |
| SCHEMBL6379364 | 0.86 | PARP1 (0.58) | PARP1DHODHPIM1KDRFLT3 | |
| SCHEMBL6380042 | 0.85 | PARP1 (0.59) | PARP1DHODHACHECHEK2PIM1 | |
| SCHEMBL6383679 | 0.84 | PARP1 (0.72) | PARP1DHODHKDRAURKB | |
| SCHEMBL6381152 | 0.83 | PARP1 (0.73) | PARP1DHODHKDRAURKB | |
| SCHEMBL6587825 | 0.83 | PARP1 (0.54) | PARP1DHODHACHECHEK2PIM1 | |
| SCHEMBL6587192 | 0.81 | PARP1 (0.50) | PARP1DHODHACHECHEK2PIM1 | |
| SCHEMBL6587474 | 0.81 | AURKB (0.54) | PARP1DHODHPIM1KDRFLT3 | |
| SCHEMBL6583586 | 0.81 | PARP1 (0.51) | PARP1DHODHACHECHEK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1127052-B1 | SUBSTITUTED 2-PHENYLBENZIMIDAZOLES, THE PRODUCTION THEREOF AND THEIR USE | ABBOTT GMBH & CO KG (DE) | 2004-12-08 | — | — | EP | disclosed |