Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9999712 | 0.87 | CYP3A4 (0.53) | CYP3A4SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL11067722 | 0.87 | CYP3A4 (0.59) | CYP3A4SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL11810790 | 0.85 | CYP3A4 (0.49) | CYP3A4SMN1; SMN2MEN1KMT2AACP1 | |
| SCHEMBL30410721 | 0.82 | CYP3A4 (0.52) | CYP3A4SMN1; SMN2MEN1KMT2AACP1 | |
| SCHEMBL16951450 | 0.81 | MEN1 (0.41) | CYP3A4SMN1; SMN2MEN1KMT2AACP1 | |
| SCHEMBL6771209 | 0.81 | TSHR (0.59) | CYP3A4SMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL91278 | 0.80 | TP53 (0.55) | CYP3A4SMN1; SMN2MEN1KMT2AACP1 | |
| SCHEMBL2170079 | 0.80 | CYP3A4 (0.50) | CYP3A4SMN1; SMN2MEN1KMT2AACP1 | |
| SCHEMBL15054592 | 0.80 | TP53 (0.55) | CYP3A4SMN1; SMN2MEN1KMT2AACP1 | |
| SCHEMBL11062715 | 0.80 | NPC1 (0.46) | CYP3A4SMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101450943-B | Method for synthesizing drug pranlukast from tetrahydrofuran path | UNIV HEBEI SCIENCE & TECH | 2012-11-07 | — | — | CN | claimed |
| CN-102304052-A | Method for preparing 5-bromo-2-hydroxy-3-nitroacetophenone | UNIV ZHEJIANG | 2012-01-04 | — | — | CN | claimed |
| CN-101450943-A | Method for synthesizing drug pranlukast from tetrahydrofuran path | UNIV HEBEI SCIENCE & TECH (CN) | 2009-06-10 | — | — | CN | claimed |
| CN-104402728-A | Preparation method for 5-chlorine-2-hydroxyl-3-nitroacetophenone | SHANDONG JINCHENG PHARMACEUTICAL & CHEMICAL CO LTD | 2015-03-11 | — | — | CN | disclosed |
| CN-101450943-B | Method for synthesizing drug pranlukast from tetrahydrofuran path | UNIV HEBEI SCIENCE & TECH | 2012-11-07 | — | — | CN | disclosed |
| CN-101781288-B | Preparation method of Pranlukast intermediate | UNIV ZHEJIANG | 2012-01-25 | — | — | CN | disclosed |
| CN-102304052-A | Method for preparing 5-bromo-2-hydroxy-3-nitroacetophenone | UNIV ZHEJIANG | 2012-01-04 | — | — | CN | disclosed |
| CN-102304052-A | Method for preparing 5-bromo-2-hydroxy-3-nitroacetophenone | UNIV ZHEJIANG | 2012-01-04 | — | — | CN | disclosed |
| CN-102304052-A | Method for preparing 5-bromo-2-hydroxy-3-nitroacetophenone | UNIV ZHEJIANG | 2012-01-04 | — | — | CN | disclosed |
| CN-101781288-A | Preparation method of Pranlukast intermediate | UNIV ZHEJIANG | 2010-07-21 | — | — | CN | disclosed |
| CN-101450943-A | Method for synthesizing drug pranlukast from tetrahydrofuran path | UNIV HEBEI SCIENCE & TECH (CN) | 2009-06-10 | — | — | CN | disclosed |
| EP-1216221-A2 | RXR MODULATORS WITH IMPROVED PHARMACOLOGIC PROFILE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2002-06-26 | — | — | EP | disclosed |
| EP-0888327-B1 | BENZOPYRAN DERIVATIVES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | MENARINI LAB (ES) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001019770-A2 | RXR MODULATORS WITH IMPROVED PHARMACOLOGIC PROFILE | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2001-03-22 | — | — | WO | disclosed |
| US-5990142-A | ANTIINFLAMMATORY AGENTS AND ANTIALLERGENS HAVING GOOD ORAL ADSORPTION AND BIOAVAILABILITY; CARDIOTONIC AND ANTIISCHEMIC AGENTS | LABORATORIOS MENARINI S.A. (ES) | 1999-11-23 | — | — | US | disclosed |
| EP-0888327-A1 | BENZOPYRAN DERIVATIVES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997034885-A1 | BENZOPYRAN DERIVATIVES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION | LABORATORIOS MENARINI S.A. (ES) | 1997-09-25 | — | — | WO | disclosed |
| US-5597929-A | Production process of 2-(tetrazol-5-yl)-4-oxo-4H-benzopyran | SUMITOMO CHEMICAL CO., LTD. (JP) | 1997-01-28 | — | — | US | disclosed |
| EP-0716088-A1 | PROCESS FOR PRODUCING 2-(TETRAZOL-5-YL)-4-OXO-4H-BENZOPYRANS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1996-06-12 | — | — | EP | disclosed |
| US-4442115-A | ANTI-ASTHMA | MAY & BAKER LIMITED (GB) | 1984-04-10 | — | — | US | disclosed |