Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11067722 | 0.96 | CYP3A4 (0.59) | CYP3A4SMN1; SMN2CES1CES2TSHR | |
| SCHEMBL6771209 | 0.89 | TSHR (0.59) | CYP3A4SMN1; SMN2CES1CES2TSHR | |
| SCHEMBL12390898 | 0.88 | CYP3A4 (0.43) | CYP3A4SMN1; SMN2CES1CES2TSHR | |
| SCHEMBL11069495 | 0.87 | NPC1 (0.59) | CYP3A4SMN1; SMN2CES1CES2TSHR | |
| SCHEMBL6577966 | 0.87 | CYP3A4 (0.46) | CYP3A4SMN1; SMN2CES1CES2TSHR | |
| SCHEMBL7629781 | 0.87 | SMN1; SMN2 (0.46) | CYP3A4SMN1; SMN2CES1CES2TSHR | |
| SCHEMBL6582839 | 0.87 | CYP3A4 (0.46) | CYP3A4SMN1; SMN2CES1CES2TSHR | |
| SCHEMBL13879003 | 0.87 | HTT (0.58) | SMN1; SMN2ALDH1A1NPC1MEN1KMT2A | |
| SCHEMBL11062715 | 0.84 | NPC1 (0.46) | CYP3A4SMN1; SMN2TSHRALDH1A1NPC1 | |
| SCHEMBL11075551 | 0.83 | VCAM1 (0.61) | CYP3A4SMN1; SMN2CES1CES2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10011560-B2 | Alternative process for the purification of an intermediate in the synthesis of non-ionic X-ray contrast agents | GE HEALTHCARE AS (NO) | 2018-07-03 | — | — | US | disclosed |
| US-9834504-B2 | Alternative process for the purification of an intermediate in the synthesis of non-ionic X-ray contrast agents | GE HEALTHCARE AS (NO) | 2017-12-05 | — | — | US | disclosed |
| US-20170253556-A1 | ALTERNATIVE PROCESS FOR THE PURIFICATION OF AN INTERMEDIATE IN THE SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS | GE HEALTHCARE AS (NO) | 2017-09-07 | — | — | US | disclosed |
| US-9695113-B2 | Alternative process for the purification of an intermediate in the synthesis of non-ionic X-ray contrast agents | GE HEALTHCARE AS (NO) | 2017-07-04 | — | — | US | disclosed |
| US-9688614-B2 | Alternative acetylation process in the synthesis of non-ionic X-ray contrast agents | GE HEALTHCARE AS (NO) | 2017-06-27 | — | — | US | disclosed |
| US-20160304438-A1 | ALTERNATIVE ACETYLATION PROCESS IN THE SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS | GE HEALTHCARE AS (NO) | 2016-10-20 | — | — | US | disclosed |
| US-20160297749-A1 | ALTERNATIVE PROCESS FOR THE PURIFICATION OF AN INTERMEDIATE IN THE SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS | GE HEALTHCARE AS (NO) | 2016-10-13 | — | — | US | disclosed |
| US-8969619-B2 | Synthesis of iodixanol in propyleneglycol | GE HEALTHCARE AS (NO) | 2015-03-03 | — | — | US | disclosed |
| US-8962886-B2 | Synthesis of iodixanol in methanol | GE HEALTHCARE AS (NO) | 2015-02-24 | — | — | US | disclosed |
| US-8962887-B2 | Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol | GE HEALTHCARE AS (NO) | 2015-02-24 | — | — | US | disclosed |
| US-7754920-B1 | Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents | GE HEALTHCARE AS (NO) | 2010-07-13 | — | — | US | disclosed |
| US-7754918-B1 | Crystallization of iodixanol in isopropanol and methanol | GE HEALTHCARE AS (NO) | 2010-07-13 | — | — | US | disclosed |
| US-7696381-B1 | Alternative dimerisation reagents for synthesis of iodixanol | GE HEALTHCARE AS (NO) | 2010-04-13 | — | — | US | disclosed |
| US-20100069669-A1 | Preparation of Iodixanol | GE HEALTHCARE AS (NO) | 2010-03-18 | — | — | US | disclosed |
| US-20090253935-A1 | PREPARATION OF IODIXANOL | GE HEALTHCARE AS (NO) | 2009-10-08 | — | — | US | disclosed |
| US-20090112022-A1 | PREPARATION OF IODIXANOL | HOMESTAD OLE MAGNE | 2009-04-30 | — | — | US | disclosed |
| US-20080300423-A1 | Purification Process of Iodixanol | GE HEALTHCARE AS (NO) | 2008-12-04 | — | — | US | disclosed |
| US-20080287711-A1 | Purification of Iodixanol | GE HEALTHCARE AS (NO) | 2008-11-20 | — | — | US | disclosed |
| US-20080161606-A1 | Preparation of iodixanol | HOMESTAD OLE MAGNE | 2008-07-03 | — | — | US | disclosed |
| US-20070203362-A1 | PREPARATION OF IODIXANOL | HOMESTAD OLE M | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069669-A1 | Preparation of Iodixanol | NISCH, DDAH1, PPIP5K2 | CYP3A4 490/4885SMN1; SMN2 4707/4885CES1 890/4885 |
| US-20160304438-A1 | ALTERNATIVE ACETYLATION PROCESS IN THE SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS | NAA15, NAT1, KAT2A | CYP3A4 2376/4885SMN1; SMN2 4604/4885CES1 1102/4885 |
| US-20160297749-A1 | ALTERNATIVE PROCESS FOR THE PURIFICATION OF AN INTERMEDIATE IN THE SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS | NISCH, PPIP5K2, IPO4 | CYP3A4 1683/4885SMN1; SMN2 4383/4885CES1 1997/4885 |
| US-20090112022-A1 | PREPARATION OF IODIXANOL | NISCH, HDHD5, INSR | CYP3A4 488/4885SMN1; SMN2 4560/4885CES1 1448/4885 |
| US-10011560-B2 | Alternative process for the purification of an intermediate in the synthesis of non-ionic X-ray contrast agents | NISCH, PPIP5K2, IPO4 | CYP3A4 1683/4885SMN1; SMN2 4383/4885CES1 1997/4885 |
| US-20080161606-A1 | Preparation of iodixanol | NISCH, HDHD5, INSR | CYP3A4 488/4885SMN1; SMN2 4560/4885CES1 1448/4885 |
| US-20070203362-A1 | PREPARATION OF IODIXANOL | NISCH, HDHD5, INSR | CYP3A4 488/4885SMN1; SMN2 4560/4885CES1 1448/4885 |
| US-20080287711-A1 | Purification of Iodixanol | NISCH, ADH1A, HDHD5 | CYP3A4 709/4885SMN1; SMN2 4722/4885CES1 1013/4885 |
| US-20080300423-A1 | Purification Process of Iodixanol | NISCH, HDHD5, ADRA2A | CYP3A4 554/4885SMN1; SMN2 4657/4885CES1 1356/4885 |
| US-20090253935-A1 | PREPARATION OF IODIXANOL | NISCH, CYP8B1, ADRA2A | CYP3A4 326/4885SMN1; SMN2 4407/4885CES1 1208/4885 |
| US-20170253556-A1 | ALTERNATIVE PROCESS FOR THE PURIFICATION OF AN INTERMEDIATE IN THE SYNTHESIS OF NON-IONIC X-RAY CONTRAST AGENTS | NISCH, PPIP5K2, IPO4 | CYP3A4 1683/4885SMN1; SMN2 4383/4885CES1 1997/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.