Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.61 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.61 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.55 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9818429 | 0.87 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL7452392 | 0.87 | CYSLTR1 (0.54) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL9081199 | 0.81 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL9363352 | 0.81 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL10662425 | 0.81 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL10689480 | 0.81 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL9843295 | 0.81 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL1004347 | 0.81 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL10683765 | 0.81 | CYSLTR1 (0.61) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL8834234 | 0.80 | GPBAR1 (0.57) | CYSLTR1CYSLTR2GPBAR1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4563526-A | PROSTAGLANDIN-SYNTHETASE INHIBITORS | FORSYTH DENTAL INFIRMARY FOR CHILDREN (US) | 1986-01-07 | — | — | US | claimed |
| US-RE31624-E | INHIBITORS OF PROSTAGLANDIN SYNTHESIS | FORSYTH DENTAL INFIRMARY FOR CHILDREN (US) | 1984-07-03 | — | — | US | claimed |
| US-4244956-A | PROSTAGLANDIN SYNTHESIS INHIBITORS | FORSYTH DENTAL INFIRMARY FOR CHILDREN (US) | 1981-01-13 | — | — | US | claimed |
| EP-0784052-B1 | Quinoline derivatives as antagonists of leukotriene d4, compositions containing the same and processes for their preparation | AVENTIS HOLDINGS INC (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-0348155-B1 | Quinoline derivatives as antagonists of leukotriene D4, compositions containing the same and processes for their preparation | RHONE POULENC RORER INT (US) | 1999-05-12 | — | — | EP | disclosed |
| EP-0784052-A1 | Quinoline derivatives as antagonists of leukotriene d4, compositions containing the same and processes for their preparation | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| US-4920131-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989012628-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0348155-A1 | Quinoline derivatives as antagonists of leukotriene D4, compositions containing the same and processes for their preparation | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1989-12-27 | — | — | EP | disclosed |
| US-4642347-A | ANTIALLERGENS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-02-10 | — | — | US | disclosed |