Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 11/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582617 | 0.91 | NAMPT (0.49) | NAMPTALDH1A1SMN1; SMN2POLBHTT | |
| SCHEMBL6582111 | 0.90 | NAMPT (0.54) | NAMPTALDH1A1SMN1; SMN2POLBHTT | |
| SCHEMBL6582624 | 0.89 | NAMPT (0.52) | NAMPTALDH1A1SMN1; SMN2POLBHTT | |
| SCHEMBL6586116 | 0.87 | NAMPT (0.54) | NAMPTALDH1A1SMN1; SMN2POLBHTT | |
| SCHEMBL6580507 | 0.87 | NAMPT (0.65) | NAMPTSMN1; SMN2POLB | |
| SCHEMBL6790569 | 0.86 | NAMPT (0.66) | NAMPTALDH1A1 | |
| SCHEMBL6583938 | 0.82 | NAMPT (0.67) | NAMPT | |
| SCHEMBL6580048 | 0.81 | NAMPT (0.49) | NAMPTALDH1A1SMN1; SMN2POLBHTT | |
| SCHEMBL6582830 | 0.81 | NAMPT (0.51) | NAMPTALDH1A1SMN1; SMN2POLBHTT | |
| SCHEMBL6902914 | 0.81 | NAMPT (0.73) | NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155012-B1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | CANCER REC TECH LTD (GB) | 2004-04-14 | — | — | EP | disclosed |
| US-6699861-B1 | ANTI-CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2004-03-02 | — | — | US | disclosed |
| EP-1155012-A1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | Cancer Research Ventures Limited (GB) | 2001-11-21 | — | — | EP | disclosed |
| WO-2000050417-A1 | ANTI-CANCER DIHYDROQUINAZOLINE DERIVATIVES | CANCER RESEARCH VENTURES LIMITED (GB) | 2000-08-31 | — | — | WO | disclosed |