Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14417823 | 0.79 | CYP2D6 (0.44) | CYP2D6SMN1; SMN2CYP2C19CYP2C9MEN1 | |
| SCHEMBL15232200 | 0.76 | KMT2A (0.42) | SMN1; SMN2CYP2C19KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL13819915 | 0.76 | CYP2D6 (0.46) | CYP2D6SMN1; SMN2CYP2C19CYP2C9MEN1 | |
| SCHEMBL598110 | 0.75 | — | — | |
| SCHEMBL3998460 | 0.75 | FFAR3 (0.52) | CYP2D6SMN1; SMN2CYP2C19CYP2C9MEN1 | |
| SCHEMBL18044505 | 0.75 | KMT2A (0.35) | SMN1; SMN2CYP2C19KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL26054136 | 0.72 | CYP2D6 (0.42) | CYP2D6SMN1; SMN2CYP2C19CYP2C9MEN1 | |
| SCHEMBL25613288 | 0.72 | CYP2D6 (0.42) | CYP2D6SMN1; SMN2CYP2C19CYP2C9MEN1 | |
| SCHEMBL26053280 | 0.72 | CYP2D6 (0.42) | CYP2D6SMN1; SMN2CYP2C19CYP2C9MEN1 | |
| SCHEMBL17970231 | 0.71 | ALDH1A1 (0.44) | CYP2D6SMN1; SMN2CYP2C19CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993460-B1 | BENZO(5,6)CYCLOHEPTA(1,2B)PYRIDINE DERIVATIVES USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE | SCHERING CORP (US) | 2004-09-15 | — | — | EP | disclosed |
| EP-0993460-A1 | BENZO(5,6)CYCLOHEPTA(1,2B)PYRIDINE DERIVATIVES USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 2000-04-19 | — | — | EP | disclosed |
| US-6051582-A | ANTITUMOR, ANTICANCER AGENTS | SCHERING CORPORATION (US) | 2000-04-18 | — | — | US | disclosed |
| WO-1998057962-A1 | BENZO(5,6)CYCLOHEPTA(1,2B)PYRIDINE DERIVATIVES USEFUL FOR INHIBITION OF FARNESYL PROTEIN TRANSFERASE | SCHERING CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |