Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 19/20 | 0.40 |
| ▸ | MAOA | P21397 | 17/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584824 | 0.72 | MAOA (0.46) | MAOBMAOA | |
| SCHEMBL426467 | 0.72 | MAOB (0.70) | MAOBMAOA | |
| SCHEMBL3604116 | 0.72 | CA9 (0.45) | MAOBMAOA | |
| SCHEMBL6585043 | 0.71 | MAOB (0.75) | MAOBMAOA | |
| SCHEMBL3604113 | 0.71 | AHR (0.31) | — | |
| SCHEMBL293145 | 0.70 | PDE3B (0.57) | MAOBMAOA | |
| SCHEMBL6585388 | 0.70 | MAOB (0.60) | MAOBMAOA | |
| SCHEMBL1040338 | 0.70 | MAOB (0.70) | MAOBMAOA | |
| SCHEMBL6588667 | 0.69 | PLCG1 (0.48) | MAOBMAOAPSEN1PSEN2APH1B | |
| SCHEMBL6585538 | 0.69 | MAOB (0.68) | MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957100-B1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | KOWA CO (JP) | 2004-10-27 | — | — | EP | disclosed |
| US-6127360-A | ANTIHISTAMINES, ANTILEUKOTRIENES, ANTIINFLAMMATORY AGENTS, ANTIASTHMATIC AGENTS | KOWA CO., LTD. (JP) | 2000-10-03 | — | — | US | disclosed |
| EP-0957100-A1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 1999-11-17 | — | — | EP | disclosed |