Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 4/20 | 0.71 |
| ▸ | AURKA | O14965 | 2/20 | 0.71 |
| ▸ | PARP1 | P09874 | 6/20 | 0.49 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | DRD3 | P35462 | 4/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.44 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.44 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | GNRHR | P30968 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6580984 | 0.97 | AURKB (0.75) | AURKBAURKAPARP1DHODHDRD2 | |
| SCHEMBL6580794 | 0.91 | AURKB (0.57) | AURKBAURKAPARP1DHODHPRKD3 | |
| SCHEMBL7819660 | 0.89 | AURKB (0.71) | AURKBAURKAPARP1DRD2DRD3 | |
| SCHEMBL6587629 | 0.89 | AURKA (0.72) | AURKBAURKAPARP1DHODHDRD2 | |
| SCHEMBL6580718 | 0.88 | AURKB (0.61) | AURKBAURKAPARP1DHODHPRKD3 | |
| SCHEMBL3582845 | 0.87 | AURKB (0.93) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6584337 | 0.87 | AURKB (0.53) | AURKBAURKAPARP1DHODHPRKD3 | |
| SCHEMBL6580774 | 0.85 | PARP1 (0.56) | AURKBAURKAPARP1DHODHPRKD3 | |
| SCHEMBL7765875 | 0.85 | AURKA (0.77) | AURKBAURKAPARP1DHODHDRD2 | |
| SCHEMBL6581295 | 0.85 | AURKB (0.56) | AURKBAURKAPARP1DHODHPRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1127052-B1 | SUBSTITUTED 2-PHENYLBENZIMIDAZOLES, THE PRODUCTION THEREOF AND THEIR USE | ABBOTT GMBH & CO KG (DE) | 2004-12-08 | — | — | EP | disclosed |