Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.93 |
| ▸ | AURKA | O14965 | 2/20 | 0.93 |
| ▸ | PARP1 | P09874 | 17/20 | 0.63 |
| ▸ | DHODH | Q02127 | 3/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3574435 | 0.96 | AURKB (1.00) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL3582843 | 0.91 | AURKB (0.76) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6804561 | 0.88 | AURKB (0.93) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL6583299 | 0.87 | AURKB (0.71) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL3582276 | 0.87 | AURKB (0.82) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL3582854 | 0.86 | AURKB (0.70) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL3577220 | 0.86 | AURKA (0.71) | AURKBAURKAPARP1DHODHPARP2 | |
| SCHEMBL7820409 | 0.85 | AURKA (0.67) | AURKBAURKAPARP1 | |
| SCHEMBL3585484 | 0.85 | PARP1 (0.75) | AURKBAURKAPARP1DHODHKDR | |
| SCHEMBL3587286 | 0.84 | AURKA (0.76) | AURKBAURKAPARP1DHODHPARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781596-B1 | Substituted 2-phenylbenzimidazoles, the production thereof and their use | ABBOTT LABORATORIES (US) | 2010-08-24 | — | — | US | disclosed |