Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROS1 | P08922 | 1/20 | 0.53 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 11/20 | 0.47 |
| ▸ | GLS | O94925 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583327 | 0.94 | ROS1 (0.55) | ROS1RPS6KB1TRPV1GLSKDM4E | |
| SCHEMBL4030518 | 0.89 | ROS1 (0.64) | ROS1RPS6KB1TRPV1GLSKDM4E | |
| SCHEMBL6581740 | 0.83 | TRPV1 (0.66) | TRPV1 | |
| SCHEMBL4023702 | 0.81 | ROS1 (0.61) | ROS1RPS6KB1TRPV1GLSMTNR1A | |
| SCHEMBL4030337 | 0.80 | TRPV1 (0.69) | ROS1RPS6KB1TRPV1GLSDGAT2 | |
| SCHEMBL4019570 | 0.79 | ROS1 (0.69) | ROS1RPS6KB1TRPV1GLSKDM4E | |
| SCHEMBL4023632 | 0.77 | ROS1 (0.57) | ROS1RPS6KB1TRPV1GLSKDM4E | |
| SCHEMBL6584430 | 0.77 | TRPV1 (0.74) | TRPV1 | |
| SCHEMBL4023210 | 0.77 | TRPV1 (0.69) | ROS1RPS6KB1TRPV1ALDH1A1DGAT2 | |
| SCHEMBL4026467 | 0.76 | ROS1 (0.73) | ROS1RPS6KB1TRPV1DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1478363-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | Abbott Laboratories (US) | 2004-11-24 | — | — | EP | claimed |
| WO-2003070247-A1 | FUSED AZABICYCLIC COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR | ABBOTT LABORATORIES (US) | 2003-08-28 | — | — | WO | claimed |