Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.64 |
| ▸ | NPC1 | O15118 | 8/20 | 0.64 |
| ▸ | RAB9A | P51151 | 8/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | PKM | P14618 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 8/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.59 |
| ▸ | GLA | P06280 | 7/20 | 0.59 |
| ▸ | TP53 | P04637 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.59 |
| ▸ | RELA | Q04206 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583378 | 1.00 | KDM4E (0.64) | KDM4EALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL8550750 | 1.00 | KDM4E (0.64) | KDM4EALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL6836872 | 0.91 | ALDH1A1 (0.57) | KDM4EALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL8551463 | 0.91 | KDM4E (0.54) | KDM4EALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL8551466 | 0.91 | KDM4E (0.54) | KDM4EALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL6836874 | 0.91 | ALDH1A1 (0.57) | KDM4EALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL6587391 | 0.90 | SMN1; SMN2 (0.57) | KDM4EALDH1A1NPC1RAB9AL3MBTL1 | |
| SCHEMBL6582335 | 0.90 | SMN1; SMN2 (0.57) | KDM4EALDH1A1NPC1RAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL8550512 | 0.88 | KDM4E (0.55) | KDM4EALDH1A1NPC1RAB9AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL8550521 | 0.88 | KDM4E (0.55) | KDM4EALDH1A1NPC1RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846689-B1 | Benzimidazole compounds | PFIZER (US) | 2004-01-14 | — | — | EP | claimed |
| EP-0846689-A1 | Benzimidazole compounds | PFIZER INC. (US) | 1998-06-10 | — | — | EP | claimed |
| EP-0846689-B1 | Benzimidazole compounds | PFIZER (US) | 2004-01-14 | — | — | EP | disclosed |
| EP-0846689-A1 | Benzimidazole compounds | PFIZER INC. (US) | 1998-06-10 | — | — | EP | disclosed |