Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 5/20 | 0.38 |
| ▸ | ACHE | P22303 | 5/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583594 | 1.00 | TACR1 (0.47) | TACR1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL6584594 | 0.91 | TACR1 (0.47) | TACR1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL8169993 | 0.91 | TACR1 (0.47) | TACR1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL6585066 | 0.82 | NPC1 (0.48) | TACR1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6587458 | 0.82 | TACR1 (0.42) | TACR1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL6587469 | 0.82 | TACR1 (0.42) | TACR1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL6585056 | 0.82 | NPC1 (0.48) | TACR1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8171945 | 0.77 | TACR1 (0.41) | TACR1MEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL6961996 | 0.74 | MEN1 (0.47) | TACR1MEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL6585848 | 0.73 | NPC1 (0.49) | TACR1KMT2ASLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865430-B1 | 3-(4-SUBST.-PIPERIDINYL-1)-1-(3,4-DICHLOROPHENYL)PROPYL CARBAMATES AND UREAS AND DERIVATIVES AS NOVEL NEUROKININ ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-03-03 | — | — | EP | disclosed |
| US-6090824-A | Therapeutic neurokinin receptor antagonist compounds | ZENECA LIMITED (GB) | 2000-07-18 | — | — | US | disclosed |