Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587458 | 1.00 | TACR1 (0.42) | TACR1CYP3A4RECQLSMN1; SMN2CYP1A2 | |
| SCHEMBL8171945 | 0.94 | TACR1 (0.41) | TACR1CYP3A4RECQLSMN1; SMN2CYP1A2 | |
| SCHEMBL8171941 | 0.85 | TACR1 (0.41) | TACR1CYP3A4RECQLSMN1; SMN2CYP1A2 | |
| SCHEMBL6585056 | 0.84 | NPC1 (0.48) | TACR1CYP3A4SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL6585066 | 0.84 | NPC1 (0.48) | TACR1CYP3A4SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL6583594 | 0.82 | TACR1 (0.47) | TACR1CYP3A4KMT2AMEN1NPC1 | |
| SCHEMBL6583595 | 0.82 | TACR1 (0.47) | TACR1CYP3A4KMT2AMEN1NPC1 | |
| SCHEMBL6585577 | 0.75 | S1PR3 (0.43) | SMN1; SMN2PKMALDH1A1MAPTHTT | |
| SCHEMBL6585584 | 0.75 | S1PR3 (0.43) | SMN1; SMN2PKMALDH1A1MAPTHTT | |
| SCHEMBL6585842 | 0.75 | NPC1 (0.49) | TACR1CYP3A4SMN1; SMN2KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865430-B1 | 3-(4-SUBST.-PIPERIDINYL-1)-1-(3,4-DICHLOROPHENYL)PROPYL CARBAMATES AND UREAS AND DERIVATIVES AS NOVEL NEUROKININ ANTAGONISTS | ASTRAZENECA AB (SE) | 2004-03-03 | — | — | EP | disclosed |
| EP-0865430-A1 | 3-(4-SUBST.-PIPERIDINYL-1)-1-(3,4-DICHLOROPHENYL)PROPYL CARBAMATES AND UREAS AND DERIVATIVES AS NOVEL NEUROKININ ANTAGONISTS | AstraZeneca AB (SE) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997019060-A1 | 3-(4-SUBST.-PIPERIDINYL-1)-1-(3,4-DICHLOROPHENYL)PROPYL CARBAMATES AND UREAS AND DERIVATIVES AS NOVEL NEUROKININ ANTAGONISTS | ZENECA LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |