Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 6/20 | 0.40 |
| ▸ | SYK | P43405 | 6/20 | 0.40 |
| ▸ | SRC | P12931 | 6/20 | 0.38 |
| ▸ | GSK3A | P49840 | 15/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585714 | 0.83 | KDR (0.44) | MAPK14SYKSRCGSK3AKDR | |
| SCHEMBL6585819 | 0.83 | KDR (0.40) | MAPK14SYKSRCGSK3AKDR | |
| SCHEMBL6584730 | 0.81 | GSK3A (0.43) | MAPK14SYKSRCGSK3AHCK | |
| SCHEMBL6587587 | 0.81 | SYK (0.44) | MAPK14SYKSRCGSK3AHCK | |
| SCHEMBL6583148 | 0.81 | GSK3A (0.42) | MAPK14SYKSRCGSK3AHCK | |
| SCHEMBL6583633 | 0.80 | GSK3A (0.45) | MAPK14SYKSRCGSK3AHCK | |
| SCHEMBL6583161 | 0.80 | GSK3A (0.42) | MAPK14SYKSRCGSK3AHCK | |
| SCHEMBL6810815 | 0.77 | KDR (0.42) | MAPK14GSK3AKDR | |
| SCHEMBL6585339 | 0.76 | KDR (0.40) | MAPK14SYKSRCGSK3AKDR | |
| SCHEMBL6589214 | 0.75 | KDR (0.41) | MAPK14SYKSRCGSK3AKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004534787-A | — | — | 2004-11-18 | — | — | JP | claimed |
| EP-1414810-A2 | 1,4-DISUBSTITUTED BENZO-FUSED CYCLOALKYL UREA COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-05-06 | — | — | EP | claimed |
| WO-2002098869-A2 | 1,4-DISUBSTITUTED BENZO-FUSED CYCLOALKYL UREA COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | claimed |