Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 20/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.45 |
| ▸ | SRC | P12931 | 8/20 | 0.40 |
| ▸ | SYK | P43405 | 8/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587587 | 0.89 | SYK (0.44) | GSK3AMAPK14SRCSYKHCK | |
| SCHEMBL6583148 | 0.88 | GSK3A (0.42) | GSK3AMAPK14SRCSYKHCK | |
| SCHEMBL6584730 | 0.86 | GSK3A (0.43) | GSK3AMAPK14SRCSYKHCK | |
| SCHEMBL6583161 | 0.83 | GSK3A (0.42) | GSK3AMAPK14SRCSYKHCK | |
| SCHEMBL6585819 | 0.83 | KDR (0.40) | GSK3AMAPK14SRCSYKHCK | |
| SCHEMBL6585714 | 0.82 | KDR (0.44) | GSK3AMAPK14SRCSYKMAPK12 | |
| SCHEMBL6583630 | 0.80 | MAPK14 (0.40) | GSK3AMAPK14SRCSYKHCK | |
| SCHEMBL6581723 | 0.78 | SYK (0.38) | GSK3AMAPK14SRCSYK | |
| SCHEMBL6585511 | 0.76 | VCP (0.39) | GSK3AMAPK14SRCSYKHCK | |
| SCHEMBL6598212 | 0.76 | KDR (0.40) | GSK3AMAPK14SRCSYKHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004534787-A | — | — | 2004-11-18 | — | — | JP | claimed |
| EP-1414810-A2 | 1,4-DISUBSTITUTED BENZO-FUSED CYCLOALKYL UREA COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2004-05-06 | — | — | EP | claimed |
| WO-2002098869-A2 | 1,4-DISUBSTITUTED BENZO-FUSED CYCLOALKYL UREA COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2002-12-12 | — | — | WO | claimed |