Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 12/20 | 0.68 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.68 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.59 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087603 | 0.91 | CYSLTR1 (0.64) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL5160956 | 0.85 | CYSLTR1 (0.74) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| Hydrochloric Acid SCHEMBL7009696 | 0.84 | CYSLTR1 (0.72) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL7504604 | 0.82 | CYSLTR1 (0.58) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL10690965 | 0.82 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL10547998 | 0.81 | CYSLTR1 (1.00) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL6089876 | 0.81 | GPBAR1 (0.68) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| Water SCHEMBL28788392 | 0.81 | CYSLTR1 (0.73) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL6583310 | 0.80 | CYSLTR1 (0.78) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 | |
| SCHEMBL7454590 | 0.80 | GPBAR1 (0.74) | CYSLTR1CYSLTR2GPBAR1PDE10AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0784052-B1 | Quinoline derivatives as antagonists of leukotriene d4, compositions containing the same and processes for their preparation | AVENTIS HOLDINGS INC (US) | 2004-09-01 | — | — | EP | disclosed |
| EP-0348155-B1 | Quinoline derivatives as antagonists of leukotriene D4, compositions containing the same and processes for their preparation | RHONE POULENC RORER INT (US) | 1999-05-12 | — | — | EP | disclosed |
| EP-0784052-A1 | Quinoline derivatives as antagonists of leukotriene d4, compositions containing the same and processes for their preparation | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| US-4920131-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989012628-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0348155-A1 | Quinoline derivatives as antagonists of leukotriene D4, compositions containing the same and processes for their preparation | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1989-12-27 | — | — | EP | disclosed |