Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 9/20 | 0.76 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.76 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.67 |
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.65 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.65 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.60 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8645017 | 0.90 | CYSLTR1 (0.70) | CYSLTR1CYSLTR2PDE10AGPBAR1ALOX5AP | |
| SCHEMBL10547998 | 0.86 | CYSLTR1 (1.00) | CYSLTR1CYSLTR2PDE10AGPBAR1FFAR1 | |
| SCHEMBL10549569 | 0.86 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2PDE10AGPBAR1ALOX5AP | |
| SCHEMBL6583310 | 0.85 | CYSLTR1 (0.78) | CYSLTR1CYSLTR2PDE10AGPBAR1ALOX5AP | |
| SCHEMBL5160956 | 0.84 | CYSLTR1 (0.74) | CYSLTR1CYSLTR2PDE10AGPBAR1ALOX5 | |
| SCHEMBL9189491 | 0.84 | CYSLTR1 (0.57) | CYSLTR1CYSLTR2PDE10AGPBAR1ALOX5AP | |
| SCHEMBL9469819 | 0.84 | CYSLTR1 (0.57) | CYSLTR1CYSLTR2PDE10AGPBAR1ALOX5AP | |
| SCHEMBL4159309 | 0.84 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2PDE10AGPBAR1ALOX5 | |
| SCHEMBL10547699 | 0.84 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2PDE10AGPBAR1ALOX5 | |
| SCHEMBL7715797 | 0.84 | CYSLTR1 (0.76) | CYSLTR1CYSLTR2PDE10AGPBAR1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0223368-A1 | Substituted naphthalene derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-27 | — | — | EP | claimed |
| US-4732978-A | RESPIRATORY SYSTEM DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-03-22 | — | — | US | disclosed |
| EP-0223368-A1 | Substituted naphthalene derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-05-27 | — | — | EP | disclosed |