SCHEMBL6583791

SCHEMBL6583791

COC(=O)c1ccc2c(-c3nc4c(OC(N)=O)cccc4[nH]3)c[nH]c2c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ASH1L Q9NR48 1/20 0.53
PDGFRB P09619 1/20 0.44
PARP1 P09874 7/20 0.44
EIF2AK2 P19525 2/20 0.44
KIF11 P52732 1/20 0.43
NPC1 O15118 2/20 0.42
ATP4A P20648 1/20 0.40
ATP4B P51164 1/20 0.40
HPSE Q9Y251 1/20 0.39
IMPDH2 P12268 1/20 0.39
PKN1 Q16512 1/20 0.39
PKN2 Q16513 1/20 0.39
GPR84 Q9NQS5 1/20 0.39
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
PKM P14618 1/20 0.38
HPGD P15428 1/20 0.38
NFKB1 P19838 1/20 0.38
RAB9A P51151 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6810193 0.86 PARP1 (0.55) ASH1LPARP1PKN1PKN2
SCHEMBL6588173 0.83 PARP1 (0.49) PARP1HPSEALDH1A1
SCHEMBL6585146 0.80 PARP1 (0.47) PARP1ATP4AATP4BHPSE
SCHEMBL6585330 0.78 PARP1 (0.43) PARP1ATP4AATP4BALDH1A1SMN1; SMN2
SCHEMBL14023513 0.77 PARP1 (0.50) ASH1LPDGFRBPARP1EIF2AK2KIF11
SCHEMBL6810200 0.76 ASH1L (0.54) ASH1LPDGFRBPARP1EIF2AK2KIF11
SCHEMBL14091584 0.75 KDM4E (0.55) ASH1LPARP1KIF11NPC1GPR84
SCHEMBL7479706 0.75 PARP1 (0.49) PARP1HPSE
SCHEMBL12601826 0.73 RAF1 (0.59) ASH1LPDGFRBEIF2AK2KIF11KDM4E
SCHEMBL6590617 0.71 PARP1 (0.48) PARP1HPSE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1177178-B1 HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF ABBOTT GMBH & CO KG (DE) 2004-12-29 EP disclosed
EP-1177178-A1 HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF BASF AKTIENGESELLSCHAFT (DE) 2002-02-06 EP disclosed
WO-2001082877-A2 USE OF PARP INHIBITORS IN COSMETIC PREPARATIONS BASF AKTIENGESELLSCHAFT (DE) 2001-11-08 WO disclosed
WO-2000068206-A1 HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF BASF AKTIENGESELLSCHAFT (DE) 2000-11-16 WO disclosed