Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.55 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.55 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6583791 | 0.86 | ASH1L (0.53) | PARP1ASH1LPKN1PKN2 | |
| SCHEMBL6810200 | 0.85 | ASH1L (0.54) | PARP1ASH1L | |
| SCHEMBL6802028 | 0.81 | PARP1 (0.66) | PARP1PKN1PKN2 | |
| SCHEMBL6805072 | 0.80 | PARP1 (0.65) | PARP1PKN1PKN2PLA2G2AALOX15 | |
| SCHEMBL28840576 | 0.80 | PARP1 (0.77) | PARP1PKN1PKN2PLA2G2AALOX15 | |
| SCHEMBL29790457 | 0.80 | PARP1 (0.77) | PARP1PKN1PKN2PLA2G2AALOX15 | |
| SCHEMBL14023513 | 0.78 | PARP1 (0.50) | PARP1ASH1L | |
| SCHEMBL14091584 | 0.77 | KDM4E (0.55) | PARP1ASH1L | |
| SCHEMBL658640 | 0.76 | PARP1 (0.56) | PARP1PKN1PKN2PLA2G2AALOX15 | |
| SCHEMBL6807494 | 0.76 | PARP1 (0.63) | PARP1PKN1PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |