Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 8/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.39 |
| ▸ | CHRNB3 | Q05901 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586600 | 0.91 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL2300523 | 0.91 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL2185913 | 0.91 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL3358944 | 0.87 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL6585018 | 0.86 | ALOX5AP (0.37) | UCHL1ALOX5APGPR119 | |
| SCHEMBL6587123 | 0.85 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL2495176 | 0.85 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL3357692 | 0.85 | CHRNB2 (0.61) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| Hydrochloric Acid SCHEMBL6584130 | 0.84 | CHRNB2 (0.60) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 | |
| SCHEMBL6583433 | 0.83 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934308-B1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2004-08-11 | — | — | EP | disclosed |