SCHEMBL6584370

SCHEMBL6584370

CC(O)CNC(=O)N1CC(Oc2ccc(F)cc2)C1

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.45
EPHX2 P34913 4/20 0.44
ACACB O00763 2/20 0.42
PRMT5 O14744 1/20 0.40
WDR77 Q9BQA1 1/20 0.40
MLNR O43193 2/20 0.39
SCN9A Q15858 1/20 0.39
GRIN1 Q05586 2/20 0.39
GRIN2B Q13224 2/20 0.39
HRH3 Q9Y5N1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6584366 1.00 CHRNA7 (0.45) CHRNA7EPHX2ACACBPRMT5WDR77
SCHEMBL6585234 0.88 EPHX2 (0.47) CHRNA7EPHX2ACACBPRMT5WDR77
SCHEMBL6585239 0.88 EPHX2 (0.47) CHRNA7EPHX2ACACBPRMT5WDR77
SCHEMBL6586275 0.88 EPHX2 (0.47) CHRNA7EPHX2ACACBPRMT5WDR77
SCHEMBL6587359 0.87 KCNH2 (0.46) CHRNA7EPHX2ACACB
SCHEMBL6588089 0.87 KCNH2 (0.46) CHRNA7EPHX2ACACB
SCHEMBL6586144 0.85 ACACB (0.50) CHRNA7ACACBPRMT5WDR77
SCHEMBL6586148 0.85 ACACB (0.50) CHRNA7ACACBPRMT5WDR77
SCHEMBL6585993 0.82 CCR3 (0.45) CHRNA7EPHX2HRH3
SCHEMBL6585997 0.82 CCR3 (0.45) CHRNA7EPHX2HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1049671-B1 AZETIDINECARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS VERNALIS RES LTD (GB) 2004-04-21 EP claimed
US-6514961-B1 Such as anxiety and all forms of epilepsy, particularly in humans VERNALIS RESEARCH LIMITED (GB) 2003-02-04 US claimed
EP-1049671-A1 AZETIDINECARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS VERNALIS RESEARCH LIMITED (GB) 2000-11-08 EP claimed
WO-1999037614-A1 AZETIDINECARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS VERNALIS RESEARCH LIMITED (GB) 1999-07-29 WO claimed
EP-1049671-B1 AZETIDINECARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS VERNALIS RES LTD (GB) 2004-04-21 EP disclosed
US-6514961-B1 Such as anxiety and all forms of epilepsy, particularly in humans VERNALIS RESEARCH LIMITED (GB) 2003-02-04 US disclosed
EP-1049671-A1 AZETIDINECARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS VERNALIS RESEARCH LIMITED (GB) 2000-11-08 EP disclosed
WO-1999037614-A1 AZETIDINECARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS VERNALIS RESEARCH LIMITED (GB) 1999-07-29 WO disclosed