Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | ACACB | O00763 | 7/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.41 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587359 | 1.00 | KCNH2 (0.46) | KCNH2MCHR1ACACBCHRNA7LIPE | |
| SCHEMBL9595931 | 0.92 | KCNH2 (0.47) | KCNH2MCHR1ACACBCHRNA7LIPE | |
| SCHEMBL6586144 | 0.89 | ACACB (0.50) | ACACBCHRNA7 | |
| SCHEMBL6586148 | 0.89 | ACACB (0.50) | ACACBCHRNA7 | |
| SCHEMBL6584366 | 0.87 | CHRNA7 (0.45) | ACACBCHRNA7EPHX2 | |
| SCHEMBL6584370 | 0.87 | CHRNA7 (0.45) | ACACBCHRNA7EPHX2 | |
| SCHEMBL6584876 | 0.87 | KDM4E (0.49) | ACACBEPHX2 | |
| SCHEMBL9596025 | 0.85 | KCNH2 (0.48) | KCNH2MCHR1ACACBCHRNA7LIPE | |
| SCHEMBL6585234 | 0.84 | EPHX2 (0.47) | ACACBCHRNA7EPHX2 | |
| SCHEMBL6585239 | 0.84 | EPHX2 (0.47) | ACACBCHRNA7EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049671-B1 | AZETIDINECARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | VERNALIS RES LTD (GB) | 2004-04-21 | — | — | EP | disclosed |
| EP-1049671-A1 | AZETIDINECARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | VERNALIS RESEARCH LIMITED (GB) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999037614-A1 | AZETIDINECARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF CNS DISORDERS | VERNALIS RESEARCH LIMITED (GB) | 1999-07-29 | — | — | WO | disclosed |