Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.60 |
| ▸ | BRAF | P15056 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | RAF1 | P04049 | 8/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.57 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL177881 | 0.93 | RAB9A (0.59) | KDRBRAFTP53MAPK14NPC1 | |
| SCHEMBL5006751 | 0.91 | RAF1 (0.63) | KDRBRAFTP53RAF1MAPK14 | |
| SCHEMBL5008981 | 0.91 | RAF1 (0.71) | KDRBRAFTP53RAF1MAPK14 | |
| SCHEMBL177679 | 0.89 | KDR (0.59) | KDRBRAFTP53RAF1MAPK14 | |
| SCHEMBL4169778 | 0.87 | RAB9A (0.70) | KDRBRAFTP53MAPK14NPC1 | |
| SCHEMBL1381739 | 0.85 | KDR (0.60) | KDRBRAFTP53RAF1MAPK14 | |
| SCHEMBL177853 | 0.81 | RAB9A (0.69) | KDRBRAFTP53RAF1MAPK14 | |
| SCHEMBL8341660 | 0.78 | RAB9A (0.81) | TP53NPC1RAB9ASMN1; SMN2GBA1 | |
| SCHEMBL257978 | 0.76 | RAF1 (0.65) | TP53RAF1MAPK14NPC1RAB9A | |
| SCHEMBL5006752 | 0.76 | MAPK14 (0.57) | KDRBRAFTP53RAF1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379505-A2 | INHIBITION OF RAF KINASE USING QUINOLYL, ISOQUINOLYL OR PYRIDYL UREAS | Bayer Corporation (US) | 2004-01-14 | — | — | EP | claimed |
| US-20030207914-A1 | INHIBITION OF RAF KINASE USING QUINOLYL, ISOQUINOLYL OR PYRIDYL UREAS | BAYER CORPORATION | 2003-11-06 | — | — | US | claimed |
| WO-2002085857-A2 | INHIBITION OF RAF KINASE USING QUINOLYL, ISOQUINOLYL OR PYRIDYL UREAS | BAYER CORPORATION (US) | 2002-10-31 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207914-A1 | INHIBITION OF RAF KINASE USING QUINOLYL, ISOQUINOLYL OR PYRIDYL UREAS | BRAF, RAF1, ARAF | KDR 1420/4885BRAF 1/4885TP53 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.