SCHEMBL6584569

SCHEMBL6584569

C=Cc1cc(OC[C@H]2CCCN2C)cnc1Cl

nearest known ligand 0.69

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CHRNA3 P32297 5/20 0.62
CHRNB4 P30926 4/20 0.62
CHRNA7 P36544 1/20 0.62
CHRNB2 P17787 5/20 0.59
CHRNA4 P43681 4/20 0.59
CHRNB1 P11230 2/20 0.59
CHRNB3 Q05901 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6581677 1.00 CHRNA3 (0.62) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
Hydrochloric Acid SCHEMBL6587349 0.99 CHRNA3 (0.61) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
Hydrochloric Acid SCHEMBL6584855 0.99 CHRNA3 (0.61) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL6587061 0.84 CHRNB4 (0.55) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL7674765 0.84 CHRNB4 (0.55) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL6587065 0.84 CHRNB4 (0.55) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL7674761 0.84 CHRNB4 (0.55) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL6586493 0.84 CHRNB4 (0.60) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL7826052 0.84 CHRNB4 (0.72) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4
SCHEMBL7817031 0.84 CHRNB4 (0.72) CHRNA3CHRNB4CHRNA7CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US claimed
EP-0934308-B1 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION ABBOTT LAB (US) 2004-08-11 EP disclosed
US-6437138-B1 5-BROMO-6-CHLORO-3-(2-(S)-AZETIDINYL OR PYRROLIDINYL-METHOXY) PYRIDINE INTERMEDIATES FOR THE 5-SUBSTITUTED COMPOUNDS WHICH ARE POTENT LIGANDS AT NEURONAL NICOTINIC CHOLINERGIC CHANNEL RECEPTORS, NEUROTRANSMITTER CONTROLLING AGENTS ABBOTT LABORATORIES 2002-08-20 US disclosed
US-6127386-A STIMULANTS, NEUROTRANSMITTERS, CHOLINERGIC AGENTS ABBOTT LABORATORIES (US) 2000-10-03 US disclosed