Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.44 |
| ▸ | GCGR | P47871 | 2/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.43 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6169396 | 0.88 | MAPK14 (0.54) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL5641941 | 0.82 | GRM1 (0.40) | MAPK14MAPK10KDM4ECYP3A4HSD17B10 | |
| SCHEMBL5639626 | 0.78 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5139712 | 0.74 | MAPK14 (0.66) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL11553308 | 0.73 | ALDH1A1 (0.48) | GSK3BKDM4ECYP3A4 | |
| SCHEMBL5104405 | 0.72 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL6582427 | 0.71 | MAPK14 (0.58) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL6168483 | 0.71 | MAPK14 (0.56) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL5640212 | 0.70 | MAPK14 (0.41) | MAPK14MAPK10MAPK13MAPK12MAPK11 | |
| SCHEMBL6584791 | 0.70 | MAPK14 (0.58) | MAPK14MAPK10MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362045-B1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2004-11-17 | — | — | EP | disclosed |