Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BRD2 | P25440 | 1/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17503197 | 0.88 | GAA (0.45) | GAATSHRMAPTALDH1A1BRD4 | |
| SCHEMBL17503195 | 0.88 | GAA (0.45) | GAATSHRMAPTALDH1A1BRD4 | |
| SCHEMBL17503193 | 0.88 | GAA (0.45) | GAATSHRMAPTALDH1A1BRD4 | |
| SCHEMBL17503246 | 0.88 | GAA (0.45) | GAATSHRMAPTALDH1A1BRD4 | |
| SCHEMBL17503245 | 0.88 | GAA (0.45) | GAATSHRMAPTALDH1A1BRD4 | |
| SCHEMBL4197722 | 0.86 | LMNA (0.39) | TSHRMAPTALDH1A1BRD4BRD2 | |
| SCHEMBL6278089 | 0.86 | LMNA (0.39) | TSHRMAPTALDH1A1BRD4BRD2 | |
| SCHEMBL4127615 | 0.86 | LMNA (0.39) | TSHRMAPTALDH1A1BRD4BRD2 | |
| SCHEMBL6975204 | 0.86 | LMNA (0.39) | TSHRMAPTALDH1A1BRD4BRD2 | |
| SCHEMBL4123720 | 0.86 | LMNA (0.39) | TSHRMAPTALDH1A1BRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377553-A1 | TETRAHYDROQUINOLINE DERIVATIVES AS STAT6-MODULATORS, PREPARATION AND USE THEREOF | AstraZeneca AB (SE) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002079165-A1 | TETRAHYDROQUINOLINE DERIVATIVES AS STAT6-MODULATORS, PREPARATION AND USE THEREOF | ASTRAZENECA AB (SE) | 2002-10-10 | — | — | WO | disclosed |