SCHEMBL658466

SCHEMBL658466

CCCC1(C)CC(C)(C)CC(C)(N)C1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27795289 0.84 TSHR (0.31)
SCHEMBL466011 0.81 KDM4E (0.30)
SCHEMBL657925 0.77
SCHEMBL8749785 0.76
SCHEMBL12221302 0.74
SCHEMBL31674978 0.74 NPC1 (0.33)
SCHEMBL658142 0.73
SCHEMBL8227607 0.71
SCHEMBL339609 0.71
SCHEMBL20756316 0.71

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 113 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9453017-B2 Antiviral therapies with phospholipase D inhibitors VANDERBILT UNIVERSITY (US) 2016-09-27 US claimed
EP-2260839-A2 Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors Merz Pharma GmbH & Co. KGaA (DE) 2010-12-15 EP claimed
EP-1682109-B1 THE USE OF 1-AMINOCYCLOHEXANE DERIVATIVES TO MODIFY DEPOSITION OF FIBRILLOGENIC AS PEPTIDES IN AMYLOIDOPATHIES MERZ PHARMA GMBH & CO KGAA (DE) 2008-10-15 EP claimed
EP-1838297-A1 1-AMINOCYCLOHEXANE-DERIVATIVES FOR THE TREATMENT OF MULTIPLE SCLEROSIS EMOTIONAL LABILITY AND PSEUDOBULBAR AFFECT Merz Pharma GmbH & Co. KGaA (DE) 2007-10-03 EP claimed
US-20070082956-A1 The use of 1-amino-alkylcyclohexane compounds in the treatment of pain hypersensitivity. MERZ PHARMA GMBH & CO. KGAA (DE) 2007-04-12 US claimed
US-20060205822-A1 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect FOREST LABORATORIES, INC. (US) 2006-09-14 US claimed
EP-1682109-A1 THE USE OF 1-AMINOCYCLOHEXANE DERIVATIVES TO MODIFY DEPOSITION OF FIBRILLOGENIC AS PEPTIDES IN AMYLOIDOPATHIES Merz Pharma GmbH & Co. KGaA (DE) 2006-07-26 EP claimed
WO-2006069294-A1 1-AMINOCYCLOHEXANE-DERIVATIVES FOR THE TREATMENT OF MULTIPLE SCLEROSIS EMOTIONAL LABILITY AND PSEUDOBULBAR AFFECT MERZ PHARMA GMBH & CO. KGAA (DE) 2006-06-29 WO claimed
EP-1660058-A2 THE USE OF 1-AMINO-ALKYLCYCLOHEXANE COMPOUNDS IN THE TREATMENT OF PAIN HYPERSENSITIVITY Merz Pharma GmbH &amp; Co. KGaA (DE) 2006-05-31 EP claimed
WO-2005079779-A1 THE USE OF 1-AMINOCYCLOHEXANE DERIVATIVES TO MODIFY DEPOSITION OF FIBRILLOGENIC Aß PEPTIDES IN AMYLOIDOPATHIES MERZ PHARMA GMBH & CO. KGAA (DE) 2005-09-01 WO claimed
EP-1556019-A2 COMBINATION THERAPY USING 1-AMINOCYCLOHEXANE DERIVATIVES AND ACETYLCHOLINESTERASE INHIBITORS Merz Pharma GmbH &amp; Co. KGaA (DE) 2005-07-27 EP claimed
US-20050113458-A1 delivering to said cell an 1-aminocyclohexane derivative; for decreasing the level of at least one amyloid peptide produced by a mammalian cell that expresses amyloid precursor protein FOREST LABORATORIES, INC. (US) 2005-05-26 US claimed
WO-2005009421-A2 THE USE OF 1-AMINO-ALKYLCYCLOHEXANE COMPOUNDS IN THE TREATMENT OF PAIN HYPERSENSITIVITY MERZ PHARMA GMBH & CO. KGAA (DE) 2005-02-03 WO claimed
EP-1318800-B1 1-AMINO-ALKYLCYCLOHEXANES AS TRYPANOCIDAL AGENTS MERZ PHARMA GMBH & CO KGAA (DE) 2005-01-26 EP claimed
WO-2004037234-A2 COMBINATION THERAPY USING 1-AMINOCYCLOHEXANE DERIVATIVES AND ACETYLCHOLINESTERASE INHIBITORS MERZ PHARMA GMBH & CO. KGAA (DE) 2004-05-06 WO claimed
US-20040087658-A1 Synergistic mixture; Alzheimer's disease therapy MERZ PHARMA GMBH & CO. KGAA (DE) 2004-05-06 US claimed
US-6602862-B1 1-Amino-alkylcyclohexanes as trypanocidal agents MERZ PHARMA GMBH & CO., KGAA (DE) 2003-08-05 US claimed
EP-1318800-A1 1-AMINO-ALKYLCYCLOHEXANES AS TRYPANOCIDAL AGENTS MERZ + CO. GmbH &amp; Co. (DE) 2003-06-18 EP claimed
WO-2002024186-A1 1-AMINO-ALKYLCYCLOHEXANES AS TRYPANOCIDAL AGENTS MERZ PHARMA GMBH & CO. KGAA (DE) 2002-03-28 WO claimed
US-20210169864-A1 COMBINATION THERAPY USING 1-AMINOCYCLOHEXANE DERIVATIVES AND ACETYLCHOLINESTERASE INHIBITORS MERZ PHARMA GMBH & CO KGAA (DE) 2021-06-10 US disclosed
US-20170319611-A1 METHODS AND COMPOSITIONS COMPRISING AKT INHIBITORS AND/OR PHOSPHOLIPASE D INHIBITORS UNIV VANDERBILT (US) 2017-11-09 US disclosed
US-20170027885-A1 1-AMINOCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF COCHLEAR TINNITUS MERZ PHARMA GMBH & CO. KGAA (DE) 2017-02-02 US disclosed
US-9498450-B2 1-aminocyclohexane derivatives for the treatment of cochlear tinnitus MERZ PHARMA GMBH & CO. KGAA (DE) 2016-11-22 US disclosed
US-9468610-B2 1-aminocyclohexane derivatives for the treatment of hearing loss MERZ PHARMA GMBH & CO. KGAA (DE) 2016-10-18 US disclosed
US-9453017-B2 Antiviral therapies with phospholipase D inhibitors VANDERBILT UNIVERSITY (US) 2016-09-27 US disclosed
EP-2386299-B1 1-Amino-Alkylcyclohexane derivatives for use in the treatment of tinnitus associated with hearing loss MERZ PHARMA GMBH & CO KGAA (DE) 2016-07-13 EP disclosed
US-20160136144-A1 COMBINATION THERAPY USING 1-AMINOCYCLOHEXANE DERIVATIVES AND ACETYLCHOLINESTERASE INHIBITORS MERZ PHARMA GMBH & CO. KGAA (DE) 2016-05-19 US disclosed
EP-2548552-B1 Titration package for 1-amino-alkylcyclohexanes MERZ PHARMA GMBH & CO KGAA (DE) 2015-11-18 EP disclosed
EP-2931277-A1 METHODS AND COMPOSITIONS COMPRISING AKT INHIBITORS AND/OR PHOSPHOLIPASE D INHIBITORS Vanderbilt University (US) 2015-10-21 EP disclosed
US-20150025041-A1 ANTIVIRAL THERAPIES WITH PHOSPHOLIPASE D INHIBITORS VANDERBILT UNIVERSITY (US) 2015-01-22 US disclosed
US-20140378524-A1 METHODS AND COMPOSITIONS COMPRISING AKT INHIBITORS AND/OR PHOSPHOLIPASE D INHIBITORS VANDERBILT UNIVERSITY 2014-12-25 US disclosed
US-20140371260-A1 COMBINATION THERAPY USING 1-AMINOCYCLOHEXANE DERIVATIVES AND ACETYLCHOLINESTERASE INHIBITORS MERZ PHARMA GMBH & CO. KGAA (GE) 2014-12-18 US disclosed
US-20140348932-A1 IMMEDIATE RELEASE FORMULATIONS OF 1-AMINOCYCLOHEXANE COMPOUNDS, MEMANTINE AND NERAMEXANE FOREST LAB HOLDINGS LTD (BM) 2014-11-27 US disclosed
US-20140350114-A1 COMPOSITIONS COMPRISING CYCLOHEXYLAMINES AND AMINOADAMANTANES MERZ PHARMA GMBH & CO KGAA (DE) 2014-11-27 US disclosed
US-8877814-B2 Titration package for neramexane and its use in the treatment of an inner ear disorder MERZ PHARMA GMBH & CO. KGAA (DE) 2014-11-04 US disclosed
US-8834924-B2 Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane FOREST LABORATORIES HOLDINGS LIMITED (BM) 2014-09-16 US disclosed
EP-2203163-B1 Titration package for neramexane and its use in the treatment of an inner ear disorder MERZ PHARMA GMBH & CO KGAA (DE) 2014-08-27 EP disclosed
US-20140228440-A1 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY SKIN DISEASES MERZ PHARMA GMBH & CO. KGAA (DE) 2014-08-14 US disclosed
EP-2760447-A1 ANTIVIRAL THERAPIES WITH PHOSPHOLIPASE D INHIBITORS Vanderbilt University (US) 2014-08-06 EP disclosed
EP-2373304-B1 Neramexane for the treatment of mast cell mediated diseases MERZ PHARMA GMBH & CO KGAA (DE) 2014-07-30 EP disclosed
WO-2014093557-A1 METHODS AND COMPOSITIONS COMPRISING AKT INHIBITORS AND/OR PHOSPHOLIPASE D INHIBITORS VANDERBILT UNIVERSITY (US) 2014-06-19 WO disclosed
US-8680149-B2 1-amino-alkylcyclohexane derivatives for the treatment of mast cell mediated diseases MERZ PHARMA GMBH & CO. KGAA (DE) 2014-03-25 US disclosed
US-20130165522-A1 GEL FORMULATIONS FOR THE TOPICAL USE OF 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES MERZ PHARMA GMBH & CO. KGAA (DE) 2013-06-27 US disclosed
US-20130158124-A1 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF MAST CELL MEDIATED DISEASES MERZ PHARMA GMBH & CO. KGAA (DE) 2013-06-20 US disclosed
US-20130150449-A1 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY SKIN DISEASES MERZ PHARMA GMBH & CO. KGAA (DE) 2013-06-13 US disclosed
EP-2601937-A1 Drinkable immediate release tablet made with direct compression of memantine or neramexane Merz Pharma GmbH & Co. KGaA (DE) 2013-06-12 EP disclosed
EP-2582356-A1 GEL FORMULATIONS FOR THE TOPICAL USE OF 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES Merz Pharma GmbH & Co. KGaA (DE) 2013-04-24 EP disclosed
WO-2013049773-A1 ANTIVIRAL THERAPIES WITH PHOSPHOLIPASE D INHIBITORS VANDERBILT UNIVERSITY (US) 2013-04-04 WO disclosed
US-8399519-B2 1-amino-alkylcyclohexane derivatives for the treatment of mast cell mediated diseases MERZ PHARMA GMBH & CO. KGAA (DE) 2013-03-19 US disclosed
US-8394857-B2 1-amino-alkylcyclohexane derivatives for the treatment of inflammatory skin diseases MERZ PHARMA GMBH & CO. KGAA (DE) 2013-03-12 US disclosed
EP-2548552-A2 Titration package for 1-amino-alkylcylohexanes Merz Pharma GmbH & Co. KGaA (DE) 2013-01-23 EP disclosed
US-20120238631-A1 COMPOSITIONS COMPRISING CYCLOHEXYLAMINES AND AMINOADAMANTANES MERZ PHARMA GMBH & CO. KGAA (DE) 2012-09-20 US disclosed
US-20120046302-A1 METHODS OF TREATING CNS DISORDERS PAPADAKIS KELLY (US) 2012-02-23 US disclosed
WO-2011157449-A1 GEL FORMULATIONS FOR THE TOPICAL USE OF 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES MERZ PHARMA GMBH & CO. KGAA (DE) 2011-12-22 WO disclosed
EP-2397122-A2 Formulations of neramexane dosage forms Merz Pharma GmbH & Co. KGaA (DE) 2011-12-21 EP disclosed
EP-2386299-A2 1-Amino-Alkylcyclohexane derivatives for the treatment of cochlear tinnitus Merz Pharma GmbH & Co. KGaA (DE) 2011-11-16 EP disclosed
EP-2200600-B1 NERAMEXANE FOR USE IN THE TREATMENT OF SUB-ACUTE TINNITUS MERZ PHARMA GMBH & CO KGAA (DE) 2011-11-09 EP disclosed
US-20110254236-A1 GROUNDED CHUCK LAM RESEARCH AG (AT) 2011-10-20 US disclosed
US-20110251283-A1 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF MAST CELL MEDIATED DISEASES MERZ PHARMA GMBH & CO., KGAA 2011-10-13 US disclosed
US-20110236439-A1 Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane FOREST LABORATORIES HOLDINGS LIMITED (BM) 2011-09-29 US disclosed
US-20110207793-A1 1-AMINOCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF SLEEP DISORDERS. MERZ PHARMA GMBH & CO. KGAA (DE) 2011-08-25 US disclosed
US-20110201665-A1 Compositions, Methods, and Kits for Treating Influenza Viral Infections COMBINATORX (SINGAPORE) PTE. LTD. (SG) 2011-08-18 US disclosed
US-20110178179-A1 1-AMINO-ALKYLCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF COGNITIVE IMPAIRMENT IN TINNITUS MERZ PHARMA GMBH & CO. KGAA (DE) 2011-07-21 US disclosed
US-20110092600-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING AMINOCYCLOHEXANE DERIVATIVES MERZ PHARMA GMBH & KGAA (DE) 2011-04-21 US disclosed
US-20110086916-A1 INTERVAL THERAPY FOR THE TREATMENT OF TINNITUS MERZ PHARMA GMBH & CO. KGAA (DE) 2011-04-14 US disclosed
US-20110077304-A1 1-AMINOCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF COCHLEAR TINNITUS. MERZ PHARMA GMBH & CO., KGAA (DE) 2011-03-31 US disclosed
EP-2289489-A2 Compositions comprising cyclohexylamines and aminoadamantanes Merz Pharma GmbH & Co. KGaA (DE) 2011-03-02 EP disclosed
US-20110028510-A1 Compositions, Methods, and Kits for Treating Influenza Viral Infections COMBINATORX (SINGAPORE) PTE. LTD. (SG) 2011-02-03 US disclosed
WO-2011001258-A1 COMPOSITIONS, METHODS, AND KITS FOR TREATING VIRAL AND BACTERIAL INFECTIONS BY TOCOTRIENOLS, TOCOMONOENOLS, TOCODIENOLS, TOCOPHEROLS, AND THEIR DERIVATES EVITA LIFE SCIENCE PTE. LTD (SG) 2011-01-06 WO disclosed
EP-2260839-A2 Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors Merz Pharma GmbH & Co. KGaA (DE) 2010-12-15 EP disclosed
EP-2260844-A1 Combination of an NMDA Receptor Antagonist and a Selective Serotonin Reuptake Inhibitor for the Treatment of Depression and other Mood Disorders Merz Pharma GmbH & Co. KGaA (DE) 2010-12-15 EP disclosed
US-20100298441-A1 TITRATION PACKAGE FOR NERAMEXANE AND ITS USE IN THE TREATMENT OF AN INNER EAR DISORDER MERZ PHARMA GMBH & CO. KGAA (DE) 2010-11-25 US disclosed
US-20100298440-A1 1-AMINOCYCLOHEXANE DERIVATIVES FOR THE TREATMENT OF HEARING LOSS MERZ PHARMA GMBH & CO., KGAA (DE) 2010-11-25 US disclosed
WO-2010126527-A1 METHODS OF TREATING CNS DISORDERS FOREST LABORATORIES HOLDINGS LIMITED (BM) 2010-11-04 WO disclosed
US-20100234358-A1 NERAMEXANE FOR THE TREATMENT OF NYSTAGMUS MERZ PHARMA GMBH & CO. KGAA (DE) 2010-09-16 US disclosed
US-20100227852-A1 Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors MERZ PHARMA GMBH & CO. KGAA (DE) 2010-09-09 US disclosed
US-20100197792-A1 1-Amino-Alkylcyclohexane derivatives for the treatment of inflammatory skin diseases MERZ PHARMA GMBH & CO. KGAA (DE) 2010-08-05 US disclosed
US-20100076073-A1 Combination of an NMDA receptor antagonist and a selective serotonin reuptake inhibitor for the treatment of depression and other mood disorders MERZ PHARMA GMBH & CO. KGAA (DE) 2010-03-25 US disclosed
US-20100035995-A1 Compositions comprising Cyclohexylamines and Aminoadamantanes MERZ PHARMA GMBH & CO. KGAA (DE) 2010-02-11 US disclosed
US-20100028427-A1 IMMEDIATE RELEASE FORMULATIONS OF 1-AMINOCYCLOHEXANE COMPOUNDS, MEMANTINE AND NERAMEXANE FOREST LABORATORIES, INC. (US) 2010-02-04 US disclosed
US-20090275597-A1 METHODS OF TREATING CNS DISORDERS FOREST LABORATORIES HOLDINGS LIMITED (BE) 2009-11-05 US disclosed
EP-2111858-A1 Novel treatment for alzheimer's disease EPFL Ecole Polytechnique Fédérale de Lausanne (CH) 2009-10-28 EP disclosed
US-20090124659-A1 Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase and inhibitors MERZ PHARMA GMBH & CO. KGAA (DE) 2009-05-14 US disclosed
US-20090081259-A1 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect MERZ PHARMA GMBH & CO. KGAA (DE) 2009-03-26 US disclosed
EP-1682109-B1 THE USE OF 1-AMINOCYCLOHEXANE DERIVATIVES TO MODIFY DEPOSITION OF FIBRILLOGENIC AS PEPTIDES IN AMYLOIDOPATHIES MERZ PHARMA GMBH & CO KGAA (DE) 2008-10-15 EP disclosed
US-20070270500-A1 Compositions Comprising Cyclohexylamines and Aminoadamantanes DEDHIYA MAHENDRA G 2007-11-22 US disclosed
EP-1838297-A1 1-AMINOCYCLOHEXANE-DERIVATIVES FOR THE TREATMENT OF MULTIPLE SCLEROSIS EMOTIONAL LABILITY AND PSEUDOBULBAR AFFECT Merz Pharma GmbH & Co. KGaA (DE) 2007-10-03 EP disclosed
US-20070082956-A1 The use of 1-amino-alkylcyclohexane compounds in the treatment of pain hypersensitivity. MERZ PHARMA GMBH & CO. KGAA (DE) 2007-04-12 US disclosed
EP-1631274-A4 COMBINATION OF AN NMDA RECEPTOR ANTAGONIST AND A SELECTIVE SEROTONIN REUPTAKE INHIBITOR FOR THE TREATMENT OF DEPRESSION AND OTHER MOOD DISORDERS FOREST LABORATORIES (US) 2007-03-28 EP disclosed
EP-1765287-A2 IMMEDIATE RELEASE FORMULATIONS OF MEMANTINE ORAL DOSAGE FORMS Merz Pharma GmbH & Co. KGaA (DE) 2007-03-28 EP disclosed
US-20060270742-A1 Compositions and methods for the treatment of neurodegenerative diseases COMBINATORX, INC. 2006-11-30 US disclosed
WO-2006119295-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES COMBINATORX, INCORPORATED (US) 2006-11-09 WO disclosed
WO-2006096194-A2 DRINKABLE IMMEDIATE RELEASE TABLET MADE WITH DIRECT COMPRESSION OF MEMANTINE OR NERAMEXANE MERZ PHARMA GMBH & CO. KGAA (DE) 2006-09-14 WO disclosed
US-20060205822-A1 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect FOREST LABORATORIES, INC. (US) 2006-09-14 US disclosed
US-20060198884-A1 Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane FOREST LABORATORIES, INC. (US) 2006-09-07 US disclosed
EP-1684715-A2 COMPOSITIONS COMPRISING CYCLOHEXYLAMINES AND AMINOADAMANTANES Merz Pharma GmbH &amp; Co. KGaA (DE) 2006-08-02 EP disclosed
EP-1682109-A1 THE USE OF 1-AMINOCYCLOHEXANE DERIVATIVES TO MODIFY DEPOSITION OF FIBRILLOGENIC AS PEPTIDES IN AMYLOIDOPATHIES Merz Pharma GmbH & Co. KGaA (DE) 2006-07-26 EP disclosed
WO-2006069294-A1 1-AMINOCYCLOHEXANE-DERIVATIVES FOR THE TREATMENT OF MULTIPLE SCLEROSIS EMOTIONAL LABILITY AND PSEUDOBULBAR AFFECT MERZ PHARMA GMBH & CO. KGAA (DE) 2006-06-29 WO disclosed
EP-1631274-A2 COMBINATION OF AN NMDA RECEPTOR ANTAGONIST AND A SELECTIVE SEROTONIN REUPTAKE INHIBITOR FOR THE TREATMENT OF DEPRESSION AND OTHER MOOD DISORDERS Forest Laboratories, Inc. (US) 2006-03-08 EP disclosed
US-20060002999-A1 Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane FOREST LABORATORIES, INC. (US) 2006-01-05 US disclosed
US-20050203191-A1 1-Aminocyclohexane derivatives for the treatment of agitation and other behavioral disorders, especially those associated with alzheimer's disease FOREST LABORATORIES, INC. (US) 2005-09-15 US disclosed
WO-2005079779-A1 THE USE OF 1-AMINOCYCLOHEXANE DERIVATIVES TO MODIFY DEPOSITION OF FIBRILLOGENIC Aß PEPTIDES IN AMYLOIDOPATHIES MERZ PHARMA GMBH & CO. KGAA (DE) 2005-09-01 WO disclosed
EP-1556019-A2 COMBINATION THERAPY USING 1-AMINOCYCLOHEXANE DERIVATIVES AND ACETYLCHOLINESTERASE INHIBITORS Merz Pharma GmbH &amp; Co. KGaA (DE) 2005-07-27 EP disclosed
US-20050113458-A1 delivering to said cell an 1-aminocyclohexane derivative; for decreasing the level of at least one amyloid peptide produced by a mammalian cell that expresses amyloid precursor protein FOREST LABORATORIES, INC. (US) 2005-05-26 US disclosed
WO-2005044228-A2 COMPOSITIONS COMPRISING CYCLOHEXYLAMINES AND AMINOADAMANTANES MERZ PHARMA GMBH & CO. KGAA (DE) 2005-05-19 WO disclosed
EP-1318800-B1 1-AMINO-ALKYLCYCLOHEXANES AS TRYPANOCIDAL AGENTS MERZ PHARMA GMBH & CO KGAA (DE) 2005-01-26 EP disclosed
US-20050014743-A1 Combination of an NMDA receptor antagonist and a selective serotonin reuptake inhibitor for the treatment of depression and other mood disorders FOREST LABORATORIES, INC. (US) 2005-01-20 US disclosed
WO-2005000216-A2 COMBINATION OF AN NMDA RECEPTOR ANTAGONIST AND A SELECTIVE SEROTONIN REUPTAKE INHIBITOR FOR THE TREATMENT OF DEPRESSION AND OTHER MOOD DISORDERS FOREST LABORATORIES, INC. (US) 2005-01-06 WO disclosed
WO-2004037234-A2 COMBINATION THERAPY USING 1-AMINOCYCLOHEXANE DERIVATIVES AND ACETYLCHOLINESTERASE INHIBITORS MERZ PHARMA GMBH & CO. KGAA (DE) 2004-05-06 WO disclosed
US-20040087658-A1 Synergistic mixture; Alzheimer's disease therapy MERZ PHARMA GMBH & CO. KGAA (DE) 2004-05-06 US disclosed
US-6602862-B1 1-Amino-alkylcyclohexanes as trypanocidal agents MERZ PHARMA GMBH & CO., KGAA (DE) 2003-08-05 US disclosed
EP-1318800-A1 1-AMINO-ALKYLCYCLOHEXANES AS TRYPANOCIDAL AGENTS MERZ + CO. GmbH &amp; Co. (DE) 2003-06-18 EP disclosed
WO-2002024186-A1 1-AMINO-ALKYLCYCLOHEXANES AS TRYPANOCIDAL AGENTS MERZ PHARMA GMBH & CO. KGAA (DE) 2002-03-28 WO disclosed
WO-2002024186-A1 1-AMINO-ALKYLCYCLOHEXANES AS TRYPANOCIDAL AGENTS MERZ PHARMA GMBH & CO. KGAA (DE) 2002-03-28 WO disclosed