Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14638683 | 0.84 | — | — | |
| SCHEMBL658466 | 0.81 | — | — | |
| SCHEMBL8749785 | 0.80 | — | — | |
| SCHEMBL12221302 | 0.78 | — | — | |
| SCHEMBL466043 | 0.75 | — | — | |
| SCHEMBL6256959 | 0.75 | — | — | |
| SCHEMBL8227607 | 0.75 | — | — | |
| SCHEMBL339609 | 0.74 | — | — | |
| SCHEMBL20756316 | 0.74 | — | — | |
| Neramexane SCHEMBL466073 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 221 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9453017-B2 | Antiviral therapies with phospholipase D inhibitors | VANDERBILT UNIVERSITY (US) | 2016-09-27 | — | — | US | claimed |
| US-20130123541-A1 | METHOD OF PREPARING 3,3,5,5-TETRAMETHYLCYCLOHEXANONE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2013-05-16 | — | — | US | claimed |
| US-20120130130-A1 | METHOD OF PREPARING NERAMEXANE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-05-24 | — | — | US | claimed |
| US-20120123166-A1 | METHOD OF PREPARING 1-HYDROXY-1,3,3,5,5-PENTAMETHYLCYCLOHEXANE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-05-17 | — | — | US | claimed |
| US-20120116125-A1 | METHOD OF PREPARING NERAMEXANE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-05-10 | — | — | US | claimed |
| EP-2448910-A1 | METHOD OF PREPARING NERAMEXANE | Merz Pharma GmbH & Co. KGaA (DE) | 2012-05-09 | — | — | EP | claimed |
| US-20110033422-A1 | TREATMENTS FOR FLAVIVIRIDAE VIRUS INFECTION | SCHERING CORPORATION | 2011-02-10 | — | — | US | claimed |
| EP-2277850-A1 | 1-amino-alkylcyclohexanes as 5-HT3 and neuronal nicotinic receptor antagonists | Merz Pharma GmbH & Co. KGaA (DE) | 2011-01-26 | — | — | EP | claimed |
| WO-2011000538-A1 | METHOD OF PREPARING NERAMEXANE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2011-01-06 | — | — | WO | claimed |
| EP-2260839-A2 | Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors | Merz Pharma GmbH & Co. KGaA (DE) | 2010-12-15 | — | — | EP | claimed |
| WO-2004009062-A2 | NMDA RECEPTOR ANTAGONISTS AND THEIR USE IN INHIBITING ABNORMAL HYPERPHOSPHORYLATION OF MICROTUBULE ASSOCIATED PROTEIN tau | IQBAL KHALID (US) | 2004-01-29 | — | — | WO | claimed |
| US-20040019118-A1 | NMDA receptor antagonists and their use in inhibiting abnormal hyperphosphorylation of microtubule associated protein tau | IQBAL KHALID (US) | 2004-01-29 | — | — | US | claimed |
| CN-1136187-C | 1-amino-alkylcyclohexane NMDA receptor antagonists | Ī�Ĺɷݹ�˾ | 2004-01-28 | — | — | CN | claimed |
| CN-1461213-A | 1-amino-alkylcyclohexanes as trypanocidal agents | MERZ & CO GMBH & CO (DE) | 2003-12-10 | — | — | CN | claimed |
| US-6602862-B1 | 1-Amino-alkylcyclohexanes as trypanocidal agents | MERZ PHARMA GMBH & CO., KGAA (DE) | 2003-08-05 | — | — | US | claimed |
| EP-1009732-B1 | 1-AMINO-ALKYLCYCLOHEXANE NMDA RECEPTOR ANTAGONISTS | MERZ & CO GMBH & CO (DE) | 2003-05-21 | — | — | EP | claimed |
| CN-1266423-A | 1-amino-alkylcyclohexane NMDA receptor antagonists | MERZ & CO GMBH & CO (DE) | 2000-09-13 | — | — | CN | claimed |
| EP-1009732-A2 | 1-AMINO-ALKYLCYCLOHEXANE NMDA RECEPTOR ANTAGONISTS | MERZ + CO. GmbH & Co. (DE) | 2000-06-21 | — | — | EP | claimed |
| US-6034134-A | 1-Amino-alkylcyclohexane NMDA receptor antagonists | MERZ + CO. GMBH & CO. (DE) | 2000-03-07 | — | — | US | claimed |
| WO-1999001416-A2 | 1-AMINO-ALKYLCYCLOHEXANE NMDA RECEPTOR ANTAGONISTS | MERZ + CO. GMBH & CO. (DE) | 1999-01-14 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110033422-A1 | TREATMENTS FOR FLAVIVIRIDAE VIRUS INFECTION | HAVCR2, EIF2AK2, HNRNPC | KDM4E 4072/4885LMNA 2114/4885CYP2C19 3960/4885 |
| US-20130123541-A1 | METHOD OF PREPARING 3,3,5,5-TETRAMETHYLCYCLOHEXANONE | NT5C3B, PPIP5K2, TET3 | KDM4E 1547/4885LMNA 1028/4885CYP2C19 464/4885 |
| US-20040019118-A1 | NMDA receptor antagonists and their use in inhibiting abnormal hyperphosphorylation of microtubule associated protein tau | GRIN2A, GRIN1, MAPT | KDM4E 2477/4885LMNA 3937/4885CYP2C19 4876/4885 |
| US-20120130130-A1 | METHOD OF PREPARING NERAMEXANE | DHPS, TOP1, NME1 | KDM4E 3578/4885LMNA 907/4885CYP2C19 1525/4885 |
| US-20120123166-A1 | METHOD OF PREPARING 1-HYDROXY-1,3,3,5,5-PENTAMETHYLCYCLOHEXANE | HVCN1, HTR1D, HTR1F | KDM4E 2242/4885LMNA 878/4885CYP2C19 1808/4885 |
| US-20120116125-A1 | METHOD OF PREPARING NERAMEXANE | NUDT1, NT5C3B, NME1 | KDM4E 3214/4885LMNA 1473/4885CYP2C19 1349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.