Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.79 |
| ▸ | GAA | P10253 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | CASP1 | P29466 | 3/20 | 0.56 |
| ▸ | CASP7 | P55210 | 3/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 2/20 | 0.52 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.52 |
| ▸ | CCR4 | P51679 | 6/20 | 0.52 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5325401 | 0.90 | KDM4E (0.64) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL3786044 | 0.88 | KDM4E (1.00) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL8745756 | 0.82 | KDM4E (0.64) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL8745801 | 0.82 | KDM4E (0.64) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL4706717 | 0.82 | KDM4E (0.64) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL28646880 | 0.81 | HSD17B3 (0.79) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL5085562 | 0.79 | KDM4E (0.72) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL14317879 | 0.78 | KDM4E (0.76) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL5327916 | 0.78 | KDM4E (0.81) | KDM4EALDH1A1MAPTGAAHPGD | |
| SCHEMBL5328894 | 0.78 | KDM4E (0.81) | KDM4EALDH1A1MAPTGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001774-B1 | USE OF PHOSPHOLAMBAN INHIBITORS FOR INCREASING CORONARY FLOW | ORION CORP (FI) | 2004-09-15 | — | — | EP | disclosed |
| US-6774103-B1 | Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors) | ORION CORPORATION (FI) | 2004-08-10 | — | — | US | disclosed |
| CN-1143857-C | Bisethers of 1-oxa, aza and thianaphthalen-2-ones as phospholamban inhibitors | ���ŷ� | 2004-03-31 | — | — | CN | disclosed |
| US-6538022-B1 | Three-dimensional structure of the cytosolic domain of phospholamban (PLB) and its active site from NMR data of sufficiently high resolution for the three-dimensional structure determination. rational drug design enabling the | ORION CORPORATION (FI) | 2003-03-25 | — | — | US | disclosed |
| EP-1039884-B1 | A METHOD FOR THE PREVENTION AND TREATMENT OF STUNNED MYOCARDIUM | ORION CORP (FI) | 2002-09-18 | — | — | EP | disclosed |
| US-6265421-B1 | DILATATION OF ARTERIES | ORION CORPORATION (FI) | 2001-07-24 | — | — | US | disclosed |
| CN-1271357-A | bisethers of 1-oxa, aza and thianaphthalen-2-ones as phospholamban inhibitors | ORION CORP (FI) | 2000-10-25 | — | — | CN | disclosed |
| US-5968959-A | ADMINISTERING PHOSPHOLAMBAN INHIBITOR | ORION CORPORATION (FI) | 1999-10-19 | — | — | US | disclosed |