Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 16/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.54 |
| ▸ | PRKACA | P17612 | 6/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 6/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.54 |
| ▸ | PIM1 | P11309 | 5/20 | 0.54 |
| ▸ | CLK2 | P49760 | 4/20 | 0.54 |
| ▸ | PRKX | P51817 | 4/20 | 0.54 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.54 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.54 |
| ▸ | CHUK | O15111 | 3/20 | 0.54 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 4/20 | 0.53 |
| ▸ | STK17A | Q9UEE5 | 4/20 | 0.53 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.53 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8508803 | 0.94 | AKT1 (0.59) | AKT1ROCK2PRKACAROCK1DYRK1A | |
| SCHEMBL8508800 | 0.94 | AKT1 (0.59) | AKT1ROCK2PRKACAROCK1DYRK1A | |
| SCHEMBL8507932 | 0.79 | AKT1 (0.50) | AKT1ROCK2PRKACAROCK1DYRK1A | |
| SCHEMBL8508136 | 0.78 | AKT1 (0.49) | AKT1ROCK2ROCK1DYRK1APIM1 | |
| SCHEMBL3916101 | 0.77 | AKT1 (0.54) | AKT1ROCK2PRKACAROCK1DYRK1A | |
| SCHEMBL3921195 | 0.77 | AKT1 (0.54) | AKT1ROCK2PRKACAROCK1DYRK1A | |
| SCHEMBL8508179 | 0.77 | AKT1 (0.54) | AKT1ROCK2PRKACAROCK1DYRK1A | |
| SCHEMBL8508178 | 0.77 | AKT1 (0.54) | AKT1ROCK2PRKACAROCK1DYRK1A | |
| Hydrochloric Acid SCHEMBL8507893 | 0.77 | AKT1 (0.48) | AKT1ROCK2ROCK1DYRK1APIM1 | |
| SCHEMBL8507102 | 0.77 | AKT1 (0.39) | AKT1ROCK2PRKACAROCK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934308-B1 | 3-PYRIDYLOXYMETHYL HETEROCYCLIC ETHER COMPOUNDS USEFUL IN CONTROLLING CHEMICAL SYNAPTIC TRANSMISSION | ABBOTT LAB (US) | 2004-08-11 | — | — | EP | disclosed |