Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | KLK5 | Q9Y337 | 3/20 | 0.45 |
| ▸ | KLK7 | P49862 | 2/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27491559 | 1.00 | PPARA (0.50) | PPARACTSSPPARGKLK5KLK7 | |
| SCHEMBL6584598 | 1.00 | PPARA (0.50) | PPARACTSSPPARGKLK5KLK7 | |
| SCHEMBL6584493 | 0.91 | PPARA (0.51) | PPARACTSSPPARGKLK5KLK7 | |
| SCHEMBL6584496 | 0.91 | PPARA (0.51) | PPARACTSSPPARGKLK5KLK7 | |
| SCHEMBL6585203 | 0.91 | PPARA (0.51) | PPARACTSSPPARGKLK5KLK7 | |
| SCHEMBL6584927 | 0.84 | BCHE (0.45) | RAB9AL3MBTL1BCHEACHE | |
| SCHEMBL1001282 | 0.80 | PPARA (0.63) | PPARACTSSPPARGKLK5KLK7 | |
| SCHEMBL1000339 | 0.80 | PPARA (0.63) | PPARACTSSPPARGKLK5KLK7 | |
| SCHEMBL272967 | 0.80 | PPARA (0.63) | PPARACTSSPPARGKLK5KLK7 | |
| SCHEMBL18407225 | 0.80 | PPARA (0.69) | PPARACTSSPPARGKLK5KLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815080-B1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA (IT) | 2004-06-16 | — | — | EP | disclosed |
| US-6002009-A | Di-substituted 1,4-piperidine esters and amides having 5-HT4 antagonistic activity | BOEHRINGER INGELHEIM ITALIA, S.P.A. (IT) | 1999-12-14 | — | — | US | disclosed |
| WO-1996028424-A1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1996-09-19 | — | — | WO | disclosed |