Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 14/20 | 0.67 |
| ▸ | DRD4 | P21917 | 9/20 | 0.64 |
| ▸ | DRD2 | P14416 | 6/20 | 0.64 |
| ▸ | DRD3 | P35462 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7481715 | 0.99 | GRM2 (0.65) | GRM2DRD4DRD2DRD3LMNA | |
| SCHEMBL6583086 | 0.95 | GRM2 (0.61) | GRM2DRD4DRD2DRD3LMNA | |
| SCHEMBL5156990 | 0.89 | GRM2 (0.81) | GRM2DRD4DRD2DRD3LMNA | |
| SCHEMBL14374007 | 0.86 | GRM2 (0.72) | GRM2DRD4DRD2DRD3LMNA | |
| SCHEMBL4139937 | 0.85 | GRM2 (0.70) | GRM2DRD4DRD2DRD3LMNA | |
| SCHEMBL4144179 | 0.82 | GRM2 (0.75) | GRM2DRD4DRD2DRD3LMNA | |
| SCHEMBL15730124 | 0.82 | GRM2 (0.71) | GRM2DRD4DRD2DRD3LMNA | |
| SCHEMBL18306578 | 0.82 | POLB (0.51) | GRM2DRD4DRD2DRD3LMNA | |
| SCHEMBL8228148 | 0.82 | ALDH1A1 (0.50) | GRM2LMNAGAAPOLBSMN1; SMN2 | |
| SCHEMBL4162812 | 0.81 | GRM2 (0.65) | GRM2DRD4DRD2DRD3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957100-B1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | KOWA CO (JP) | 2004-10-27 | — | — | EP | disclosed |
| EP-0957100-A1 | DIAMINE DERIVATIVES AND PHARMACEUTICAL CONTAINING THE SAME | Kowa Co., Ltd. (JP) | 1999-11-17 | — | — | EP | disclosed |