Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MME | P08473 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584531 | 0.86 | CCKBR (0.45) | TSHRFOLH1MEN1KMT2APRMT5 | |
| SCHEMBL6588576 | 0.76 | KMT2A (0.33) | KMT2AALDH1A1 | |
| SCHEMBL6584673 | 0.70 | ACACB (0.36) | KMT2AALDH1A1 | |
| SCHEMBL6584496 | 0.68 | PPARA (0.51) | MEN1KMT2APPARAL3MBTL1CTSS | |
| SCHEMBL6585203 | 0.68 | PPARA (0.51) | MEN1KMT2APPARAL3MBTL1CTSS | |
| SCHEMBL6584493 | 0.68 | PPARA (0.51) | MEN1KMT2APPARAL3MBTL1CTSS | |
| SCHEMBL27491559 | 0.68 | PPARA (0.50) | MEN1KMT2APPARAL3MBTL1CTSS | |
| SCHEMBL6584598 | 0.68 | PPARA (0.50) | MEN1KMT2APPARAL3MBTL1CTSS | |
| SCHEMBL23385710 | 0.67 | KMT2A (0.51) | TSHRMEN1KMT2AALDH1A1PRMT5 | |
| SCHEMBL16758733 | 0.67 | FOLH1 (0.51) | TSHRFOLH1CNR1PPARAMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0815080-B1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA (IT) | 2004-06-16 | — | — | EP | disclosed |
| US-6002009-A | Di-substituted 1,4-piperidine esters and amides having 5-HT4 antagonistic activity | BOEHRINGER INGELHEIM ITALIA, S.P.A. (IT) | 1999-12-14 | — | — | US | disclosed |
| EP-0815080-A1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT 4? ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996028424-A1 | DI-SUBSTITUTED 1,4-PIPERIDINE ESTERS AND AMIDES HAVING 5-HT4 ANTAGONISTIC ACTIVITY | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1996-09-19 | — | — | WO | disclosed |