Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.45 |
| ▸ | PDE4A | P27815 | 4/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | EBP | Q15125 | 2/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584276 | 0.93 | SIGMAR1 (0.50) | PDE4BPDE4DSIGMAR1EBPTMEM97 | |
| SCHEMBL6584797 | 0.85 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6585598 | 0.82 | PDE4B (0.57) | PDE4BPDE4DPDE4APDE4CSIGMAR1 | |
| SCHEMBL6588290 | 0.79 | PDE4B (0.47) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6584367 | 0.75 | PDE4B (0.54) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6585357 | 0.75 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4CSIGMAR1 | |
| SCHEMBL6586286 | 0.74 | PDE4B (0.45) | PDE4BPDE4DPDE4APDE4CSIGMAR1 | |
| SCHEMBL6585386 | 0.73 | PDE4A (0.56) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL8488126 | 0.71 | PDE4B (0.51) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7913482 | 0.69 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4CSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0928789-B1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | NIKKEN CHEMICALS CO LTD (JP) | 2004-09-29 | — | — | EP | disclosed |
| US-6251897-B1 | TREATING DERMATITIS, ASTHMA | NIKKEN CHEMICALS CO., LTD (JP) | 2001-06-26 | — | — | US | disclosed |
| EP-0928789-A1 | 6-PHENYLTETRAHYDRO-1,3-OXAZIN-2-ONE DERIVATIVES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME | Nikken Chemicals Company, Limited (JP) | 1999-07-14 | — | — | EP | disclosed |