Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 1.00 |
| ▸ | ERBB2 | P04626 | 13/20 | 1.00 |
| ▸ | FYN | P06241 | 1/20 | 0.67 |
| ▸ | SRC | P12931 | 1/20 | 0.67 |
| ▸ | BLK | P51451 | 1/20 | 0.67 |
| ▸ | BMX | P51813 | 1/20 | 0.67 |
| ▸ | JAK3 | P52333 | 1/20 | 0.67 |
| ▸ | BTK | Q06187 | 1/20 | 0.67 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30115294 | 1.00 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL867890 | 0.92 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL30115339 | 0.92 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL867889 | 0.92 | EGFR (1.00) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL16882294 | 0.90 | EGFR (0.82) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL1418149 | 0.89 | EGFR (0.80) | EGFRERBB2 | |
| SCHEMBL1418151 | 0.89 | EGFR (0.80) | EGFRERBB2 | |
| SCHEMBL1418064 | 0.89 | EGFR (0.81) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL1418066 | 0.89 | EGFR (0.81) | EGFRERBB2FYNSRCBLK | |
| SCHEMBL30115309 | 0.89 | EGFR (0.81) | EGFRERBB2FYNSRCBLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000039-B1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | WYETH CORP (US) | 2004-06-09 | — | — | EP | claimed |