Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 11/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 11/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6584791 | 0.94 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6171002 | 0.81 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11CSNK1E | |
| SCHEMBL6582884 | 0.80 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL27337778 | 0.78 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5641195 | 0.75 | MAPK14 (0.74) | MAPK14MAPK13MAPK12MAPK11MAPK10 | |
| SCHEMBL19864314 | 0.74 | MAPK14 (0.90) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5139712 | 0.74 | MAPK14 (0.66) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6169396 | 0.73 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL5097682 | 0.72 | MAPK14 (0.49) | MAPK14MAPK13MAPK12MAPK11MAPK9 | |
| SCHEMBL6168483 | 0.71 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362045-B1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2004-11-17 | — | — | EP | disclosed |
| EP-1362045-A2 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002066458-A2 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2002-08-29 | — | — | WO | disclosed |