Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | DRD4 | P21917 | 4/20 | 0.48 |
| ▸ | DRD3 | P35462 | 4/20 | 0.48 |
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | AKT2 | P31751 | 2/20 | 0.45 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5642209 | 0.85 | MAPK14 (0.59) | MAPK14DRD2DRD4DRD3AKT1 | |
| SCHEMBL5642212 | 0.85 | MAPK14 (0.59) | MAPK14DRD2DRD4DRD3AKT1 | |
| SCHEMBL6584791 | 0.84 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11CSNK1D | |
| SCHEMBL6585969 | 0.81 | MAPK14 (0.51) | MAPK14EGFRMAPK13MAPK12MAPK11 | |
| SCHEMBL4917883 | 0.80 | MAPK14 (0.71) | MAPK14EGFRMAPK13MAPK12MAPK11 | |
| SCHEMBL6169935 | 0.78 | MAPK14 (0.51) | MAPK14ALOX5MAPK13MAPK12MAPK11 | |
| SCHEMBL5098347 | 0.77 | DRD2 (0.56) | MAPK14DRD2DRD4DRD3ALOX5 | |
| SCHEMBL5850265 | 0.76 | MAPK14 (0.51) | MAPK14DRD2DRD4DRD3MAPK13 | |
| SCHEMBL8420006 | 0.76 | MAPK14 (0.58) | MAPK14DRD2DRD4DRD3AKT1 | |
| SCHEMBL1387891 | 0.73 | MAPK14 (0.64) | MAPK14DRD2DRD4DRD3AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1506187-A1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS | MERCKLE GMBH (DE) | 2005-02-16 | — | — | EP | disclosed |
| EP-1362045-B1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2004-11-17 | — | — | EP | disclosed |
| WO-2003097633-A1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS | MERCKLE GMBH (DE) | 2003-11-27 | — | — | WO | disclosed |
| EP-1362045-A2 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002066458-A2 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2002-08-29 | — | — | WO | disclosed |