Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 2/20 | 0.78 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.78 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | MGLL | Q99685 | 1/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | F2R | P25116 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10589415 | 0.86 | KCNK3 (0.79) | KCNK3KCNK9MAPK14MEN1POLB | |
| SCHEMBL31401957 | 0.85 | KCNK3 (0.83) | KCNK3KCNK9MAPK14MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL31228954 | 0.84 | KCNK3 (0.77) | KCNK3KCNK9MAPK14MEN1POLB | |
| SCHEMBL18906023 | 0.84 | KCNK3 (0.81) | KCNK3KCNK9MAPK14MEN1POLB | |
| SCHEMBL20227586 | 0.82 | KCNK3 (0.79) | KCNK3KCNK9ADORA3MGLLALOX5 | |
| SCHEMBL18152289 | 0.81 | MEN1 (0.73) | KCNK3KCNK9ADORA3MGLLALOX5 | |
| SCHEMBL14281776 | 0.81 | KCNK3 (0.71) | KCNK3KCNK9ALOX5MEN1POLB | |
| SCHEMBL31401968 | 0.80 | KCNK3 (0.70) | KCNK3KCNK9MAPK14MEN1POLB | |
| SCHEMBL8457167 | 0.78 | ADORA3 (0.71) | KCNK3KCNK9ADORA3MGLLALOX5 | |
| SCHEMBL18906013 | 0.78 | KCNK3 (0.68) | KCNK3KCNK9MAPK14MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448513-A1 | BIPHENYL-DERIVATIVES AS P38-KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-08-25 | — | — | EP | disclosed |
| EP-1435934-A1 | 5'-ACYLAMINO-1,1'-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| EP-1436272-A1 | BIPHENYLCARBOXYLIC AMIDE DERIVATIVES AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033457-A1 | BIPHENYL-DERIVATIVES AS P38-KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |
| WO-2003033483-A1 | BIPHENYLCARBOXYLIC AMIDE DERIVATIVES AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |
| WO-2003032971-A1 | 5’-ACYLAMINO-1,1’-BIPHENYL-4-CARBOXAMIDE DERIVATIVES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |