Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.45 |
| ▸ | RIOK2 | Q9BVS4 | 3/20 | 0.44 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26805734 | 0.87 | L3MBTL1 (0.49) | GCKL3MBTL1PIK3C3JAK2JAK1 | |
| SCHEMBL25046382 | 0.84 | L3MBTL1 (0.46) | GCKL3MBTL1PIK3C3JAK2JAK1 | |
| SCHEMBL30518614 | 0.84 | AAK1 (0.49) | GCKL3MBTL1PIK3C3JAK2JAK1 | |
| SCHEMBL27638921 | 0.84 | GCK (0.51) | GCKJAK2JAK1TYK2RIOK2 | |
| SCHEMBL3932265 | 0.83 | RIOK2 (0.57) | GCKL3MBTL1PIK3C3RIOK2 | |
| SCHEMBL23012567 | 0.83 | SMN1; SMN2 (0.45) | GCKL3MBTL1PIK3C3JAK2JAK1 | |
| SCHEMBL19736189 | 0.81 | HPGD (0.54) | GCKL3MBTL1PIK3C3MAPK14RIOK2 | |
| SCHEMBL14872565 | 0.81 | NPC1 (0.55) | GCKL3MBTL1PIK3C3AAK1 | |
| SCHEMBL23988961 | 0.79 | L3MBTL1 (0.47) | GCKL3MBTL1PIK3C3JAK2JAK1 | |
| SCHEMBL25912817 | 0.79 | AAK1 (0.48) | GCKL3MBTL1PIK3C3RIOK2SLC9A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362045-B1 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2004-11-17 | — | — | EP | disclosed |
| EP-1362045-A2 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2003-11-19 | — | — | EP | disclosed |
| WO-2002066458-A2 | 2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THE USE THEREOF IN THE PHARMACEUTICAL INDUSTRY | MERCKLE GMBH (DE) | 2002-08-29 | — | — | WO | disclosed |