Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 14/20 | 0.53 |
| ▸ | PPARD | Q03181 | 8/20 | 0.53 |
| ▸ | PPARG | P37231 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6582734 | 0.85 | PPARA (0.60) | PPARAPPARDPPARGKDM4EMEN1 | |
| SCHEMBL6586288 | 0.84 | PPARA (0.59) | PPARAPPARDPPARGKDM4EMEN1 | |
| SCHEMBL5185069 | 0.80 | PPARA (0.82) | PPARAPPARDPPARG | |
| SCHEMBL6581920 | 0.79 | PPARA (0.83) | PPARAPPARDPPARGKDM4EMEN1 | |
| SCHEMBL6582740 | 0.79 | PPARA (0.82) | PPARAPPARDPPARGNPC1ALDH1A1 | |
| SCHEMBL6584609 | 0.78 | PPARA (0.70) | PPARAPPARDPPARGKDM4EMEN1 | |
| SCHEMBL5216376 | 0.77 | PPARA (0.55) | PPARAPPARDPPARGKDM4EMEN1 | |
| SCHEMBL6582869 | 0.75 | PPARA (0.67) | PPARAPPARDPPARG | |
| SCHEMBL4682532 | 0.75 | PPARA (0.61) | PPARAPPARDPPARGKDM4EMEN1 | |
| SCHEMBL14445995 | 0.75 | PPARA (0.59) | PPARAPPARDPPARGKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244642-B1 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS HPPAR ALPHA ACTIVATORS | GLAXO GROUP LTD (GB) | 2004-04-28 | — | — | EP | claimed |