Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 16/20 | 0.55 |
| ▸ | PPARD | Q03181 | 7/20 | 0.55 |
| ▸ | PPARG | P37231 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219857 | 0.90 | PPARA (0.67) | PPARAPPARDPPARGNPC1ALDH1A1 | |
| SCHEMBL6582734 | 0.89 | PPARA (0.60) | PPARAPPARDPPARGNPC1ALDH1A1 | |
| SCHEMBL5185069 | 0.81 | PPARA (0.82) | PPARAPPARDPPARG | |
| SCHEMBL6582740 | 0.79 | PPARA (0.82) | PPARAPPARDPPARGNPC1ALDH1A1 | |
| SCHEMBL6582457 | 0.78 | PPARA (0.74) | PPARAPPARDPPARGNPC1ALDH1A1 | |
| SCHEMBL4830364 | 0.77 | PPARD (0.51) | PPARAPPARDPPARG | |
| SCHEMBL4826471 | 0.77 | PPARD (0.51) | PPARAPPARDPPARG | |
| SCHEMBL6586282 | 0.77 | PPARA (0.53) | PPARAPPARDPPARGNPC1ALDH1A1 | |
| SCHEMBL4826476 | 0.77 | PPARD (0.51) | PPARAPPARDPPARG | |
| SCHEMBL6583596 | 0.76 | PPARA (0.64) | PPARAPPARDPPARGNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392665-B1 | THIAZOLE OR OXAZOLE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT OF CARDIOVASCULAR AND RELATED DISEASES | GLAXO GROUP LTD (GB) | 2007-10-31 | — | — | EP | claimed |
| US-6867225-B2 | Thiazole or oxazole derivatives which are useful in the treatment of cardiovascular and related diseases | SMITHKLINE BEECHAM CORPORATION (US) | 2005-03-15 | — | — | US | claimed |
| US-20040176427-A1 | Thiazole or oxazole derivatives which are useful in the treatment of cardiovascular and related diseases | GLAXO GROUP LIMITED (GB) | 2004-09-09 | — | — | US | claimed |
| EP-1392665-B1 | THIAZOLE OR OXAZOLE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT OF CARDIOVASCULAR AND RELATED DISEASES | GLAXO GROUP LTD (GB) | 2007-10-31 | — | — | EP | disclosed |
| US-6867225-B2 | Thiazole or oxazole derivatives which are useful in the treatment of cardiovascular and related diseases | SMITHKLINE BEECHAM CORPORATION (US) | 2005-03-15 | — | — | US | disclosed |
| EP-1392665-A1 | THIAZOLE OR OXAZOLE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT OF CARDIOVASCULAR AND RELATED DISEASES | GLAXO GROUP LIMITED (GB) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002096894-A1 | THIAZOLE OR OXAZOLE DERIVATIVES WHICH ARE USEFUL IN THE TREATMENT OF CARDIOVASCULAR AND RELATED DISEASES | GLAXO GROUP LIMITED (GB) | 2002-12-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176427-A1 | Thiazole or oxazole derivatives which are useful in the treatment of cardiovascular and related diseases | NCEH1, OXER1, THOP1 | PPARA 515/4885PPARD 379/4885PPARG 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.