Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 9/20 | 0.53 |
| ▸ | MMP3 | P08254 | 9/20 | 0.53 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | USP5 | P45974 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586482 | 1.00 | MMP2 (0.53) | MMP2MMP3NAMPTALDH1A1PKM | |
| SCHEMBL6586474 | 1.00 | MMP2 (0.53) | MMP2MMP3NAMPTALDH1A1PKM | |
| SCHEMBL6588498 | 0.90 | MMP2 (0.61) | MMP2MMP3NAMPTALDH1A1PKM | |
| SCHEMBL6588492 | 0.90 | MMP2 (0.61) | MMP2MMP3NAMPTALDH1A1PKM | |
| SCHEMBL6588495 | 0.90 | MMP2 (0.61) | MMP2MMP3NAMPTALDH1A1PKM | |
| SCHEMBL6586549 | 0.87 | MMP2 (0.59) | MMP2MMP3NAMPTALDH1A1PKM | |
| SCHEMBL6586552 | 0.87 | MMP2 (0.59) | MMP2MMP3NAMPTALDH1A1PKM | |
| SCHEMBL6586544 | 0.87 | MMP2 (0.59) | MMP2MMP3NAMPTALDH1A1PKM | |
| SCHEMBL6586010 | 0.86 | MMP2 (0.53) | MMP2MMP3NAMPTALDH1A1PKM | |
| SCHEMBL6586006 | 0.86 | MMP2 (0.53) | MMP2MMP3NAMPTALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1036062-B1 | HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE (MMP) INHIBITORS | PFIZER LTD (GB) | 2004-01-02 | — | — | EP | disclosed |