Urea

Urea

SCHEMBL6586511

NC(N)=O.Nc1ccc(N)c(N)c1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 8/20 0.52
KMT2A Q03164 6/20 0.52
THRB P10828 5/20 0.52
MEN1 O00255 5/20 0.52
MAPT P10636 5/20 0.52
RECQL P46063 3/20 0.52
PKM P14618 3/20 0.52
POLB P06746 2/20 0.52
USP2 O75604 1/20 0.52
APEX1 P27695 1/20 0.52
BLM P54132 1/20 0.52
MCL1 Q07820 1/20 0.52
ALDH1A1 P00352 6/20 0.45
CYP3A4 P08684 6/20 0.45
ALOX15 P16050 6/20 0.45
CASP1 P29466 3/20 0.45
TSHR P16473 3/20 0.45
HSD17B10 Q99714 3/20 0.45
HPGD P15428 2/20 0.45
HTR6 P50406 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29371552 0.86
SCHEMBL62612 0.86
Hydrochloric Acid SCHEMBL29893542 0.83 TDP1 (0.53) TDP1KMT2ATHRBMEN1MAPT
Hydrochloric Acid SCHEMBL7035695 0.83 TDP1 (0.53) TDP1KMT2ATHRBMEN1MAPT
Hydrochloric Acid SCHEMBL29391311 0.83 TDP1 (0.53) TDP1KMT2ATHRBMEN1MAPT
Hydrochloric Acid SCHEMBL3734893 0.83 TDP1 (0.53) TDP1KMT2ATHRBMEN1MAPT
Hydrochloric Acid SCHEMBL1599797 0.83 TDP1 (0.53) TDP1KMT2ATHRBMEN1MAPT
Benzene SCHEMBL28308705 0.80 TDP1 (0.50) TDP1KMT2ATHRBMEN1MAPT
Hydrochloric Acid SCHEMBL28563060 0.80 TDP1 (0.50) TDP1KMT2ATHRBMEN1MAPT
Urea SCHEMBL8680818 0.80 TDP1 (0.48) TDP1KMT2ATHRBMEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1414791-A1 METHOD FOR THE PRODUCTION OF 1,2,4-TRIAMINOBENZOLECARBAMIC ACID ESTERS VIATRIS GmbH & Co. KG (DE) 2004-05-06 EP disclosed
WO-2003010134-A1 METHOD FOR THE PRODUCTION OF 1,2,4-TRIAMINOBENZOLECARBAMIC ACID ESTERS VIATRIS GMBH & CO. KG (DE) 2003-02-06 WO disclosed