Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | RGS12 | O14924 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL6589825 | 0.89 | ESR1 (0.37) | OPRM1OPRK1LMNAMEN1CYP3A4 | |
| Fumaric Acid SCHEMBL6592056 | 0.89 | ESR1 (0.37) | OPRM1OPRK1LMNAMEN1CYP3A4 | |
| SCHEMBL6587862 | 0.84 | EED (0.40) | EEDMAPTNPSR1LMNAHTR2A | |
| SCHEMBL6592097 | 0.82 | EED (0.38) | EEDMAPTNPSR1LMNAHTR2A | |
| SCHEMBL6587141 | 0.76 | HTR2A (0.50) | OPRM1OPRK1EEDMAPTLMNA | |
| SCHEMBL8519604 | 0.76 | EED (0.34) | EEDMAPTNPSR1LMNAHTR2A | |
| SCHEMBL6591541 | 0.76 | TIPARP (0.43) | OPRM1PRCPEEDMAPTNPSR1 | |
| Maleic Acid SCHEMBL6589717 | 0.75 | SLC6A2 (0.39) | MAPTNPSR1LMNAHTR2AKDM4E | |
| Fumaric Acid SCHEMBL6592830 | 0.75 | SLC6A2 (0.39) | MAPTNPSR1LMNAHTR2AKDM4E | |
| Fumaric Acid SCHEMBL6589530 | 0.73 | SLC6A2 (0.42) | LMNAHTR2AKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703232-B1 | 2,3-Dihydro-1H-isoindole derivates, a process for their preparation and their use as serotonin reuptake inhibitors | AVENTIS PHARMA INC (US) | 2004-06-30 | — | — | EP | claimed |