SCHEMBL658684

SCHEMBL658684

O=C(C=Cc1cccc(Cl)c1)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 1.00
CYP1B1 Q16678 5/20 0.68
BCHE P06276 2/20 0.68
MAPT P10636 2/20 0.68
PLIN1 O60240 1/20 0.68
LMNA P02545 1/20 0.68
TNFRSF1A P19438 1/20 0.68
ACHE P22303 1/20 0.68
RECQL P46063 1/20 0.68
PLIN5 Q00G26 1/20 0.68
ABHD5 Q8WTS1 1/20 0.68
CYP1A2 P05177 3/20 0.67
CYP2C9 P11712 1/20 0.67
HDAC3 O15379 1/20 0.63
HDAC4 P56524 1/20 0.63
HDAC1 Q13547 1/20 0.63
HDAC7 Q8WUI4 1/20 0.63
HDAC2 Q92769 1/20 0.63
HDAC10 Q969S8 1/20 0.63
HDAC11 Q96DB2 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11793559 1.00 MAOB (1.00) MAOBCYP1B1BCHEMAPTPLIN1
SCHEMBL658683 1.00 MAOB (1.00) MAOBCYP1B1BCHEMAPTPLIN1
SCHEMBL16939629 0.92 MAOB (0.84) MAOBCYP1B1MAPTCYP1A2CYP2C9
SCHEMBL11800073 0.90 MAOB (0.82) MAOBCYP1B1CYP1A2CYP2C9MAOA
SCHEMBL657847 0.90 MAOB (0.82) MAOBCYP1B1BCHEMAPTPLIN1
SCHEMBL657846 0.90 MAOB (0.82) MAOBCYP1B1BCHEMAPTPLIN1
SCHEMBL13203402 0.88 MAOB (0.81) MAOBCYP1B1BCHEMAPTPLIN1
SCHEMBL28110416 0.88 MAOB (0.81) MAOBCYP1B1BCHEMAPTPLIN1
SCHEMBL7304478 0.87 MAOB (0.77) MAOBCYP1B1BCHEMAPTCYP1A2
SCHEMBL30414139 0.87 MAOB (0.77) MAOBCYP1B1BCHEMAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-60244595-A None JP disclosed
CN-116199597-B Substituted phenyl diazonium salt and application thereof in catalytic preparation of 3-substituted indole compounds 盐城利民农化有限公司 2024-12-03 CN disclosed
CN-116199597-A Substituted phenyl diazonium salt and application thereof in catalytic preparation of 3-substituted indole compounds 盐城利民农化有限公司 2023-06-02 CN disclosed
CN-110590712-B Method for preparing epoxide by aerobic epoxidation of olefin by one-pot method 大连理工大学 2022-08-09 CN disclosed
CN-111892559-B Application of chiral TADDOL ligand and rare earth metal amide in combined catalysis of asymmetric reaction 苏州大学 2022-04-12 CN disclosed
CN-111892559-A Application of chiral TADDOL ligand and rare earth metal amide in combined catalysis of asymmetric reaction 苏州大学 2020-11-06 CN disclosed
CN-109851540-B Application of aryloxy functionalized prolinol chiral ligand as catalyst 苏州大学 2020-06-16 CN disclosed
CN-108084117-B Method for preparing epoxide by visible light induction 大连理工大学 2020-06-16 CN disclosed
CN-110590712-A Method for preparing epoxide by aerobic epoxidation of olefin by one-pot method 大连理工大学 2019-12-20 CN disclosed
EP-2349999-B1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIV SAARLAND (DE) 2016-01-27 EP disclosed
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2012-02-23 US disclosed
EP-2349999-A1 ALLOSTERIC PROTEIN KINASE MODULATORS Universität des Saarlandes (DE) 2011-08-03 EP disclosed
WO-2010043711-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2010-04-22 WO disclosed
EP-2177510-A1 Allosteric protein kinase modulators Universität des Saarlandes (DE) 2010-04-21 EP disclosed
US-5492915-A ANTIINFLAMMATORY AGENTS RHONE-POULENC RORER S.A. (FR) 1996-02-20 US disclosed
US-5366982-A Antiinflammatory agents or antihistamines RHONE-POULENC RORER S.A. (FR) 1994-11-22 US disclosed
US-5037824-A Cardiotonic, antiischemic agents FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1991-08-06 US disclosed
EP-0387070-A2 N-Containing heterocyclic compounds, processes for the preparation thereof and composition comprising the same FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-09-12 EP disclosed
JP-S60244595-A THERMAL RECORDING MATERIAL RICOH CO LTD 1985-12-04 JP disclosed
US-3989708-A HYPOTENSIVE, CORONARY VESSEL DILATORS BAYER AKTIENGESELLSCHAFT (DT) 1976-11-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120046307-A1 ALLOSTERIC PROTEIN KINASE MODULATORS AURKC, AURKA, AURKB MAOB 4512/4885CYP1B1 4714/4885BCHE 3330/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.