SCHEMBL658683

SCHEMBL658683

O=C(/C=C/c1cccc(Cl)c1)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 9/20 1.00
CYP1B1 Q16678 5/20 0.68
BCHE P06276 2/20 0.68
MAPT P10636 2/20 0.68
PLIN1 O60240 1/20 0.68
LMNA P02545 1/20 0.68
TNFRSF1A P19438 1/20 0.68
ACHE P22303 1/20 0.68
RECQL P46063 1/20 0.68
PLIN5 Q00G26 1/20 0.68
ABHD5 Q8WTS1 1/20 0.68
CYP1A2 P05177 3/20 0.67
CYP2C9 P11712 1/20 0.67
HDAC3 O15379 1/20 0.63
HDAC4 P56524 1/20 0.63
HDAC1 Q13547 1/20 0.63
HDAC7 Q8WUI4 1/20 0.63
HDAC2 Q92769 1/20 0.63
HDAC10 Q969S8 1/20 0.63
HDAC11 Q96DB2 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL658684 1.00 MAOB (1.00) MAOBCYP1B1BCHEMAPTPLIN1
SCHEMBL11793559 1.00 MAOB (1.00) MAOBCYP1B1BCHEMAPTPLIN1
SCHEMBL16939629 0.92 MAOB (0.84) MAOBCYP1B1MAPTCYP1A2CYP2C9
SCHEMBL11800073 0.90 MAOB (0.82) MAOBCYP1B1CYP1A2CYP2C9MAOA
SCHEMBL657847 0.90 MAOB (0.82) MAOBCYP1B1BCHEMAPTPLIN1
SCHEMBL657846 0.90 MAOB (0.82) MAOBCYP1B1BCHEMAPTPLIN1
SCHEMBL13203402 0.88 MAOB (0.81) MAOBCYP1B1BCHEMAPTPLIN1
SCHEMBL28110416 0.88 MAOB (0.81) MAOBCYP1B1BCHEMAPTPLIN1
SCHEMBL7304478 0.87 MAOB (0.77) MAOBCYP1B1BCHEMAPTCYP1A2
SCHEMBL30414139 0.87 MAOB (0.77) MAOBCYP1B1BCHEMAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111233645-A Method for preparing tri-substituted cyclopentene by MBH/Wittig domino reaction of vinylon insertion 浙江大学 2020-06-05 CN claimed
JP-60244595-A None JP disclosed
CN-114456086-B Synthesis method of beta-cyano ketone 哈尔滨理工大学 2024-10-01 CN disclosed
CN-115894345-A Method for photocatalytic synthesis of chiral aza-arene functionalized cyclobutane compound 河南工业大学 2023-04-04 CN disclosed
CN-114456086-A Synthesis method of beta-cyano ketone 哈尔滨理工大学 2022-05-10 CN disclosed
US-20210207175-A1 COMPOUND FOR REGULATING GENE EDITING EFFICIENCY AND APPLICATION THEREOF SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (CN) 2021-07-08 US disclosed
EP-3825409-A1 COMPOUND FOR REGULATING GENE EDITING EFFICIENCY AND APPLICATION THEREOF Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences (CN) 2021-05-26 EP disclosed
CN-109851540-B Application of aryloxy functionalized prolinol chiral ligand as catalyst 苏州大学 2020-06-16 CN disclosed
CN-111233645-A Method for preparing tri-substituted cyclopentene by MBH/Wittig domino reaction of vinylon insertion 浙江大学 2020-06-05 CN disclosed
WO-2019238091-A1 COMPOUND FOR REGULATING GENE EDITING EFFICIENCY AND APPLICATION THEREOF 中国科学院上海有机化学研究所 2019-12-19 WO disclosed
US-20120029197-A1 Method for Preparing Sulfur-Containing Compounds THE ROYAL COLLEGE OF SURGEONS IN IRELAND (IE) 2012-02-02 US disclosed
EP-2349999-A1 ALLOSTERIC PROTEIN KINASE MODULATORS Universität des Saarlandes (DE) 2011-08-03 EP disclosed
WO-2010066450-A1 A METHOD FOR PREPARING SULFUR-CONTAINING COMPOUNDS THE ROYAL COLLEGE OF SURGEONS IN IRELAND (IE) 2010-06-17 WO disclosed
WO-2010043711-A1 ALLOSTERIC PROTEIN KINASE MODULATORS UNIVERSITAET DES SAARLANDES (DE) 2010-04-22 WO disclosed
EP-2177510-A1 Allosteric protein kinase modulators Universität des Saarlandes (DE) 2010-04-21 EP disclosed
US-5492915-A ANTIINFLAMMATORY AGENTS RHONE-POULENC RORER S.A. (FR) 1996-02-20 US disclosed
US-5366982-A Antiinflammatory agents or antihistamines RHONE-POULENC RORER S.A. (FR) 1994-11-22 US disclosed
US-5037824-A Cardiotonic, antiischemic agents FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1991-08-06 US disclosed
EP-0387070-A2 N-Containing heterocyclic compounds, processes for the preparation thereof and composition comprising the same FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-09-12 EP disclosed
JP-S60244595-A THERMAL RECORDING MATERIAL RICOH CO LTD 1985-12-04 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120029197-A1 Method for Preparing Sulfur-Containing Compounds SULT1E1, SULT1A1, TST MAOB 1192/4885CYP1B1 353/4885BCHE 4699/4885
US-20210207175-A1 COMPOUND FOR REGULATING GENE EDITING EFFICIENCY AND APPLICATION THEREOF TET2, ZFX, ZFR MAOB 2305/4885CYP1B1 1567/4885BCHE 4312/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.