Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | TOP1 | P11387 | 3/20 | 0.69 |
| ▸ | TOP2A | P11388 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | BLM | P54132 | 2/20 | 0.62 |
| ▸ | GLA | P06280 | 2/20 | 0.62 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.62 |
| ▸ | RECQL | P46063 | 1/20 | 0.62 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.62 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.62 |
| ▸ | TERT | O14746 | 4/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6587636 | 0.95 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1TOP1TOP2AHPGD | |
| SCHEMBL18595033 | 0.94 | SMN1; SMN2 (0.77) | SMN1; SMN2ALDH1A1TOP1TOP2AHPGD | |
| SCHEMBL19484928 | 0.91 | ALDH1A1 (0.72) | SMN1; SMN2ALDH1A1TOP1TOP2AHPGD | |
| Hoechst 33258 SCHEMBL18089342 | 0.88 | ALDH1A1 (0.89) | SMN1; SMN2ALDH1A1TOP1TOP2AHPGD | |
| SCHEMBL23010423 | 0.87 | KDM4E (0.59) | SMN1; SMN2ALDH1A1TOP1TOP2AHPGD | |
| SCHEMBL24299757 | 0.86 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1TOP1TOP2AHPGD | |
| SCHEMBL19484925 | 0.85 | ALDH1A1 (0.63) | SMN1; SMN2ALDH1A1TOP1TOP2AHPGD | |
| SCHEMBL8769012 | 0.84 | ALDH1A1 (0.72) | SMN1; SMN2ALDH1A1TOP1TOP2AHPGD | |
| SCHEMBL24299677 | 0.84 | ALDH1A1 (0.62) | SMN1; SMN2ALDH1A1TOP1TOP2AHPGD | |
| SCHEMBL13290549 | 0.84 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1TOP1TOP2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9795687-B2 | Modularly assembled small molecules for the treatment of myotonic dystrophy type 1 | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-10-24 | — | — | US | disclosed |
| EP-2114896-B1 | RADIOPROTECTOR COMPOUNDS AND RELATED METHODS | PETER MACCALLUM CANCER INST (AU) | 2015-07-22 | — | — | EP | disclosed |
| US-8796277-B2 | Radioprotector compounds and related methods | PETER MACCALLUM CANCER INSTITUTE (AU) | 2014-08-05 | — | — | US | disclosed |
| WO-2008074091-A1 | RADIOPROTECTOR COMPOUNDS AND RELATED METHODS | PETER MACCALLUM CANCER INSTITUTE (AU) | 2008-06-26 | — | — | WO | disclosed |
| EP-0777656-B1 | NOVEL DNA-TARGETED ALKYLATING AGENTS | AUCKLAND DIVISION CANCER SOC O (NZ) | 2004-04-14 | — | — | EP | disclosed |
| US-5968933-A | ANTITUMOR AGENTS AND BINDING DNA FOR MUTAGENESIS | AUCKLAND DIVISION CANCER SOCIETY OF NEW ZEALAND INC. (NZ) | 1999-10-19 | — | — | US | disclosed |
| WO-1996006831-A1 | NOVEL DNA-TARGETED ALKYLATING AGENTS | AUCKLAND DIVISION CANCER SOCIETY OF NEW ZEALAND INC. (NZ) | 1996-03-07 | — | — | WO | disclosed |