Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.55 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6588373 | 0.87 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DMAOB | |
| SCHEMBL6585132 | 0.82 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4703782 | 0.82 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6589876 | 0.72 | PRMT5 (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6586051 | 0.71 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4699871 | 0.71 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6590379 | 0.69 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6587035 | 0.69 | PDE4A (0.84) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6585212 | 0.69 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6588107 | 0.69 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097142-B1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2004-10-13 | — | — | EP | disclosed |
| US-6492360-B1 | Phthalazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2002-12-10 | — | — | US | disclosed |
| US-6329370-B1 | CARDIOVASCULAR DISORDERS AND TUMOR NECROSIS FACTOR (HEREINAFTER TNF.SUB..ALPHA.), A CYTOKINE WITH PRO-INFLAMMATORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |
| EP-1097142-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000005218-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 2000-02-03 | — | — | WO | disclosed |