Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 7/20 | 0.52 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.52 |
| ▸ | AR | P10275 | 4/20 | 0.48 |
| ▸ | PDE4A | P27815 | 6/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6486531 | 0.85 | PDE4A (0.57) | PRMT5WDR77ARPDE4APDE4B | |
| SCHEMBL4703782 | 0.79 | PDE4A (0.53) | PRMT5WDR77PDE4APDE4BPDE4C | |
| SCHEMBL6587794 | 0.72 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4699871 | 0.70 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6585132 | 0.70 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL23087320 | 0.68 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL29943213 | 0.68 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL23571868 | 0.65 | AR (0.74) | PRMT5ARLMNAHTTNPSR1 | |
| SCHEMBL6589989 | 0.65 | CYP11B1 (0.53) | PRMT5WDR77ARLMNA | |
| SCHEMBL7449019 | 0.64 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097142-B1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2004-10-13 | — | — | EP | disclosed |
| US-6492360-B1 | Phthalazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2002-12-10 | — | — | US | disclosed |
| US-6329370-B1 | CARDIOVASCULAR DISORDERS AND TUMOR NECROSIS FACTOR (HEREINAFTER TNF.SUB..ALPHA.), A CYTOKINE WITH PRO-INFLAMMATORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |
| EP-1097142-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2001-05-09 | — | — | EP | disclosed |
| WO-2000005218-A1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 2000-02-03 | — | — | WO | disclosed |