Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | ECE1 | P42892 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589533 | 0.78 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DBDKRB2 | |
| SCHEMBL6585740 | 0.75 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DECE1 | |
| SCHEMBL6585696 | 0.74 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DABL1 | |
| SCHEMBL6591289 | 0.74 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DECE1 | |
| SCHEMBL6683469 | 0.74 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6588117 | 0.74 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4DABL1 | |
| SCHEMBL6589117 | 0.72 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL6584319 | 0.71 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DRAB9A | |
| SCHEMBL6587163 | 0.71 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DABL1 | |
| SCHEMBL15665976 | 0.67 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1097142-B1 | PHTHALAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON SPA (IT) | 2004-10-13 | — | — | EP | disclosed |
| US-6492360-B1 | Phthalazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2002-12-10 | — | — | US | disclosed |
| US-6329370-B1 | CARDIOVASCULAR DISORDERS AND TUMOR NECROSIS FACTOR (HEREINAFTER TNF.SUB..ALPHA.), A CYTOKINE WITH PRO-INFLAMMATORY ACTIVITY | ZAMBON GROUP S.P.A. (IT) | 2001-12-11 | — | — | US | disclosed |